ReviewEnvironmental health perspectives2000
Mutagenicity of trichloroethylene and its metabolites: implications for the risk assessment of trichloroethylene.
Review in Environmental health perspectives, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 65 citations in OpenAlex.
- Mutagenicity Assessment to Pesticide Adjuvants of Toluene, Chloroform, and Trichloroethylene by Ames Test.International journal of environmental research and public health · 2021Article
- Chemical Peels in Skin Cancer: A Review.The Journal of clinical and aesthetic dermatology · 2020Review
- Review
- Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water.Environmental science & technology · 2015Article
- Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects.Journal of toxicology and environmental health. Part A · 2015Article
- Occupational health hazards of trichloroethylene among workers in relation to altered mRNA expression of cell cycle regulating genes (p53, p21, bax and bcl-2) and PPARA.Toxicology reports · 2015Article
- Occupational health risks among trichloroethylene-exposed workers in a clock manufacturing factory.Global journal of health science · 2014Article
- In vitro cytogenetic assessment of trichloroacetic acid in human peripheral blood lymphocytes.Environmental science and pollution research international · 2014Article
- Micronucleus induction by oxidative metabolites of trichloroethylene in cultured human peripheral blood lymphocytes: a comparative genotoxicity study.Environmental science and pollution research international · 2013Article
- Genetic signature for human risk assessment: lessons from trichloroethylene.Environmental and molecular mutagenesis · 2009Review
- Remediation of BTEX and trichloroethene. Current knowledge with special emphasis on phytoremediation.Environmental science and pollution research international · 2002Review
- TCE Meta-Analyses: Wartenberg et al.'s Response.Environmental health perspectives · 2000Article
- Re: "Collision of Evidence and Assumptions: TMI Déjà View"Environmental health perspectives · 2000Article
- Bisphenol A and Dental Sealants: Olea's Response.Environmental health perspectives · 2000Article
- Trichloroethylene health risks--state of the science.Environmental health perspectives · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article addresses the evidence that trichloroethylene (TCE) or its metabolites might mediate tumor formation via a mutagenic mode of action. We review and draw conclusions from the published mutagenicity and genotoxicity information for TCE and its metabolites, chloral hydrate (CH), dichloroacetic acid (DCA), trichloroacetic acid (TCA), trichloroethanol, S-(1, 2-dichlorovinyl)-l-cysteine (DCVC), and S-(1, 2-dichlorovinyl) glutathione (DCVG). The new U.S. Environmental Protection Agency proposed Cancer Risk Assessment Guidelines provide for an assessment of the key events involved in the development of specific tumors. Consistent with this thinking, we provide a new and general strategy for interpreting genotoxicity data that goes beyond a simple determination that the chemical is or is not genotoxic. For TCE, we conclude that the weight of the evidence argues that chemically induced mutation is unlikely to be a key event in the induction of human tumors that might be caused by TCE itself (as the parent compound) and its metabolites, CH, DCA, and TCA. This conclusion derives primarily from the fact that these chemicals require very high doses to be genotoxic. There is not enough information to draw any conclusions for trichloroethanol and the two trichloroethylene conjugates, DCVC and DCVG. There is some evidence that DCVC is a more potent mutagen than CH, DCA, or TCA. Unfortunately, definitive conclusions as to whether TCE will induce tumors in humans via a mutagenic mode of action cannot be drawn from the available information. More research, including the development and use of new techniques, is required before it is possible to make a definitive assessment as to whether chemically induced mutation is a key event in any human tumors resulting from exposure to TCE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.