ArticleProceedings of the National Academy of Sciences of the United States of America2000
Neonatal lead exposure impairs development of rodent barrel field cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Gestational Chlorpyrifos Exposure Imparts Lasting Alterations to the Rat Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Monitoring and Health Risk Assessment of Lead and Cadmium in Date Palm Fruit Cultivars Growing in Morocco.Biological trace element research · 2025Article
- Review
- Preventive Effect ofFrontiers in nutrition · 2022Article
- The Role of Nrf2 on the Cognitive Dysfunction of High-fat Diet Mice Following Lead Exposure.Biological trace element research · 2021Article
- Article
- Lead-Induced Motor Dysfunction Is Associated with Oxidative Stress, Proteome Modulation, and Neurodegeneration in Motor Cortex of Rats.Oxidative medicine and cellular longevity · 2021Article
- Arsenic aggravated reproductive toxicity in male rats exposed to lead during the perinatal period.Toxicology research · 2018Article
- Dysfunction of cortical synapse-specific mitochondria in developing rats exposed to lead and its amelioration by ascorbate supplementation.Neuropsychiatric disease and treatment · 2018Article
- Perceptual Training Restores Impaired Cortical Temporal Processing Due to Lead Exposure.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Effects of chronic and acute lead treatments on the biophysical properties of erythrocyte membranes, and a comparison with model membranes.FEBS open bio · 2013Article
- Exploring potential sources of differential vulnerability and susceptibility in risk from environmental hazards to expand the scope of risk assessment.American journal of public health · 2011Article
- Decreased expression of the voltage-dependent anion channel in differentiated PC-12 and SH-SY5Y cells following low-level Pb exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Chronic low-level lead exposure affects the monoaminergic system in the mouse superior olivary complex.The Journal of comparative neurology · 2009Article
- Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function.Neurotoxicology · 2008Article
- Developmental potential in the first 5 years for children in developing countries.Lancet (London, England) · 2007Article
- Prenatal alcohol exposure (PAE) reduces the size of the forepaw representation in forepaw barrel subfield (FBS) cortex in neonatal rats: relationship between periphery and central representation.Experimental brain research · 2006Article
- Prenatal alcohol exposure alters the size, but not the pattern, of the whisker representation in neonatal rat barrel cortex.Experimental brain research · 2005Article
- Reductions in blood lead overestimate reductions in brain lead following repeated succimer regimens in a rodent model of childhood lead exposure.Environmental health perspectives · 2004Article
- The relationship between lead in plasma and whole blood in women.Environmental health perspectives · 2002Article
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Authors and funding
4 authors.
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Abstract
Childhood exposure to low-level lead can permanently reduce intelligence, but the neurobiologic mechanism for this effect is unknown. We examined the impact of lead exposure on the development of cortical columns, using the rodent barrel field as a model. In all areas of mammalian neocortex, cortical columns constitute a fundamental structural unit subserving information processing. Barrel field cortex contains columnar processing units with distinct clusters of layer IV neurons that receive sensory input from individual whiskers. In this study, rat pups were exposed to 0, 0.2, 1, 1.5, or 2 g/liter lead acetate in their dam's drinking water from birth through postnatal day 10. This treatment, which coincides with the development of segregated columns in the barrel field, produced blood lead concentrations from 1 to 31 microg/dl. On postnatal day 10, the area of the barrel field and of individual barrels was measured. A dose-related reduction in barrel field area was observed (Pearson correlation = -0.740; P < 0.001); mean barrel field area in the highest exposure group was decreased 12% versus controls. Individual barrels in the physiologically more active caudoventral group were affected preferentially. Total cortical area measured in the same sections was not altered significantly by lead exposure. These data support the hypothesis that lead exposure may impair the development of columnar processing units in immature neocortex. We demonstrate that low levels of blood lead, in the range seen in many impoverished inner-city children, cause structural alterations in a neocortical somatosensory map.
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