ArticleProceedings of the National Academy of Sciences of the United States of America2000
Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- FMRP regulation of STAT3-MYC signaling is critical for adult hippocampal neurogenesis and cognitive flexibility.Cell death and differentiation · 2026Article
- Generation and initial characterization of mice lacking full-length BAI3 (ADGRB3) expression.Basic & clinical pharmacology & toxicology · 2023Article
- Presenilin-1 (PSEN1) Mutations: Clinical Phenotypes beyond Alzheimer's Disease.International journal of molecular sciences · 2023Review
- The critical role of γ-secretase and its inhibitors in cancer and cancer therapeutics.International journal of biological sciences · 2023Review
- Social isolation reinforces aging-related behavioral inflexibility by promoting neuronal necroptosis in basolateral amygdala.Molecular psychiatry · 2022Article
- Genetic Deficiency of p53 Leads to Structural, Functional, and Synaptic Deficits in Primary Somatosensory Cortical Neurons of Adult Mice.Frontiers in molecular neuroscience · 2022Article
- Differential Role of p53 in Oligodendrocyte Survival in Response to Various Stresses: Experimental Autoimmune Encephalomyelitis, Cuprizone Intoxication or White Matter Stroke.International journal of molecular sciences · 2021Article
- Dopaminergic Neuron-Specific Deletion of p53 Gene Attenuates Methamphetamine Neurotoxicity.Neurotoxicity research · 2017Article
- Targeting Adult Neurogenesis for Poststroke Therapy.Stem cells international · 2017Review
- Is Huntingtin Dispensable in the Adult Brain?Journal of Huntington's disease · 2017Review
- MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome.Science translational medicine · 2016Article
- Control of adult neurogenesis by programmed cell death in the mammalian brain.Molecular brain · 2016Review
- α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1.The Journal of biological chemistry · 2012Article
- Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus.Cell death & disease · 2010Article
- GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress.Molecular cell · 2009Article
- Crosstalk of Notch with p53 and p63 in cancer growth control.Nature reviews. Cancer · 2009Review
- The molecular programme of tumour reversion: the steps beyond malignant transformation.Nature reviews. Cancer · 2009Review
- Alterations in presenilin 1 processing by amyloid-beta peptide in the rat retina.Experimental brain research · 2007Article
- Article
- Self-correcting maps of molecular pathways.PloS one · 2006Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Presenilin 1 (PS1) expression is repressed by the p53 tumor suppressor. As shown herein, wild-type PS1 is an effective antiapoptotic molecule capable of significantly inhibiting p53-dependent and p53-independent cell death. We analyzed, at the functional and molecular levels, the brains of p53 knockout mice. Surprisingly, we found that lack of p53 expression induces apoptotic brain lesions, accompanied by learning deficiency and behavioral alterations. p53-deficient mice show an unexpected overexpression of p21(waf1) with subsequent down-regulation of PS1 in their brains. This process is progressive and age-dependent. These data indicate that the p53 pathway, besides affecting tumor suppression, may play a major role in regulating neurobehavioral function and cell survival in the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.