ArticleProceedings of the National Academy of Sciences of the United States of America2000
An ancestral MADS-box gene duplication occurred before the divergence of plants and animals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 248 papers.
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248 citing papers in PubMed, 605 citations in OpenAlex.
- Genome-wide characterization of MADS-box genes and their roles in axillary bud development in tobacco.Plant cell reports · 2026Article
- Fruit-Specific Promoters in Plants: Advances, Regulatory Mechanisms and Applications in Plant Biotechnology.Plants (Basel, Switzerland) · 2026Review
- The other giant: functional significance and divergence of Type I MADS-box genes in the evolution of land plants.Journal of experimental botany · 2026Review
- Isolation and functional characterization of two SOC1-like genes in floral organ development of Lonicera macranthoides.Plant cell reports · 2026Article
- No Evidence Supports the Presence of SRF-type MADS-Box Genes in Land Plants.Genome biology and evolution · 2026Article
- Natural variation in the CONSTANS-like gene TaCOL1-7D modulates root growth and nitrogen uptake in wheat.Plant communications · 2026Article
- Transcriptional Regulation of Starch Biosynthesis in Sorghum Grain by a MIKC-Type MADS-Box Transcription Factor: An In Vitro Analysis.Plants (Basel, Switzerland) · 2026Article
- Identification and Expression Analysis ofPlants (Basel, Switzerland) · 2026Article
- Integrated Phylogenomic and Expression Analyses Reveal Lineage-Specific Loss of the Mβ Subfamily and Regulatory Diversification of MADS-Box Genes in Pepper.Plants (Basel, Switzerland) · 2026Article
- The PbrMADS1-PbrMYB169 complex has uniquely emerged to regulate lignification of stone cells in pear.Journal of integrative plant biology · 2026Article
- Ectopic Over-Expression ofPlants (Basel, Switzerland) · 2025Article
- Integrated Transcriptome and Metabolome Analyses Reveal the Roles of MADS-Box Genes in Regulating Flower Development and Metabolite Accumulation inCurrent issues in molecular biology · 2025Article
- Assessing Evolutionary Divergence in Genome-Wide MADS-Box Genes and Expression Profiles BetweenEcology and evolution · 2025Article
- G1-mediated OsMADS1 repression regulates sterile lemma development in rice.Plant cell reports · 2025Article
- Characterization and Phylogenetic Analysis of MADS-Box Gene Family in Magnoliids: Insights into the Evolution of Floral Morphogenesis in Angiosperms.Plants (Basel, Switzerland) · 2025Article
- Research Progress on the Regulation of Plant Floral Organ Development by theInternational journal of molecular sciences · 2025Review
- The origin, evolution, and diversification of MADS-box transcription factors in green plants.Plant communications · 2025Article
- ARABIDOPSIS HOMOLOG OF TRITHORAX1 impacts lateral root development by epigenetic regulation of targets involved in root system architecture.The New phytologist · 2025Article
- Identification of the MADS-Box Gene Family and Development of Simple Sequence Repeat Markers inPlants (Basel, Switzerland) · 2025Article
- A Novel OsMPK6-OsMADS47-PPKL1/3 Module Controls Grain Shape and Yield in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
188 more citing papers are in PubMed but not listed here.
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9 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Changes in genes encoding transcriptional regulators can alter development and are important components of the molecular mechanisms of morphological evolution. MADS-box genes encode transcriptional regulators of diverse and important biological functions. In plants, MADS-box genes regulate flower, fruit, leaf, and root development. Recent sequencing efforts in Arabidopsis have allowed a nearly complete sampling of the MADS-box gene family from a single plant, something that was lacking in previous phylogenetic studies. To test the long-suspected parallel between the evolution of the MADS-box gene family and the evolution of plant form, a polarized gene phylogeny is necessary. Here we suggest that a gene duplication ancestral to the divergence of plants and animals gave rise to two main lineages of MADS-box genes: TypeI and TypeII. We locate the root of the eukaryotic MADS-box gene family between these two lineages. A novel monophyletic group of plant MADS domains (AGL34 like) seems to be more closely related to previously identified animal SRF-like MADS domains to form TypeI lineage. Most other plant sequences form a clear monophyletic group with animal MEF2-like domains to form TypeII lineage. Only plant TypeII members have a K domain that is downstream of the MADS domain in most plant members previously identified. This suggests that the K domain evolved after the duplication that gave rise to the two lineages. Finally, a group of intermediate plant sequences could be the result of recombination events. These analyses may guide the search for MADS-box sequences in basal eukaryotes and the phylogenetic placement of new genes from other plant species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.