Evidence map›Paper›PMID 10805765›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2000

Cell signaling pathways as control modules: complexity for simplicity?

D A Lauffenburger

Abstract readComment
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Format-Preserving Reduction of Canonical Nonlinear Models.Bulletin of mathematical biology · 2026
    Article
  3. Review
  4. Canalizing kernel for cell fate determination.Briefings in bioinformatics · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. A Practical Step-by-Step Guide for Quantifying Retroactivity in Gene Networks.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  11. Article
  12. Article
  13. Conceptual Evolution of Cell Signaling.International journal of molecular sciences · 2019
    Review
  14. Pharmaceutical-based entrainment of circadian phase via nonlinear model predictive control.Automatica : the journal of IFAC, the International Federation of Automatic Control · 2019
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Communication shapes sensory response in multicellular networks.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

D A LauffenburgerDivision of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. lauffen@mit.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ChemotaxisSignal TransductionEscherichia coliFlagellaModels, Biological

Identifiers

PMID10805765
PMCPMC33983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.