ArticleMolecular and cellular biology2000
Neoplastic transformation by Notch requires nuclear localization.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 125 citations in OpenAlex.
- Current research of the Notch pathway in hepatocellular carcinoma.European journal of medical research · 2025Review
- Somatic Recombination Between an Ancient and a RecentInternational journal of molecular sciences · 2024Article
- Notch activation defines immune-suppressive subsets of ccRCCs with unfavorable benefits from immunotherapy over VEGFR/mTOR inhibitors.iScience · 2024Article
- GIT1 protects against breast cancer growth through negative regulation of Notch.Nature communications · 2022Article
- Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses.Frontiers in immunology · 2022Article
- Notch1 primes CD4 T cells for T helper type I differentiation through its early effects on miR-29.Molecular immunology · 2018Article
- The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes.Cellular and molecular gastroenterology and hepatology · 2018Article
- Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.Nature communications · 2017Article
- Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell LinesFrontiers in pharmacology · 2017Article
- Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport.Cancer research · 2016Article
- Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities.Oncogene · 2015Article
- NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.Cancer research · 2014Article
- Non-canonical notch signaling in cancer and immunity.Frontiers in oncology · 2014Review
- NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome.Frontiers in immunology · 2014Article
- Mutations in NOTCH2 in patients with Hajdu-Cheney syndrome.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Article
- Article
- Non-genetic modulation of Notch activity by artificial delivery of Notch intracellular domain into neural stem cells.Stem cell reviews and reports · 2012Article
- Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75(NTR) in a glioblastoma cell line.Experimental and therapeutic medicine · 2012Article
- Clinicopathological significance of altered Notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma.World journal of gastroenterology · 2011Article
- Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates Notch transcriptional activity.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Notch proteins are plasma membrane-spanning receptors that mediate important cell fate decisions such as differentiation, proliferation, and apoptosis. The mechanism of Notch signaling remains poorly understood. However, it is clear that the Notch signaling pathway mediates its effects through intercellular contact between neighboring cells. The prevailing model for Notch signaling suggests that ligand, presented on a neighboring cell, triggers proteolytic processing of Notch. Following proteolysis, it is thought that the intracellular portion of Notch (N(ic)) translocates to the nucleus, where it is involved in regulating gene expression. There is considerable debate concerning where in the cell Notch functions and what proteins serve as effectors of the Notch signal. Several Notch genes have clearly been shown to be proto-oncogenes in mammalian cells. Activation of Notch proto-oncogenes has been associated with tumorigenesis in several human and other mammalian cancers. Transforming alleles of Notch direct the expression of truncated proteins that primarily consist of N(ic) and are not tethered to the plasma membrane. However, the mechanism by which Notch oncoproteins (generically termed here as N(ic)) induce neoplastic transformation is not known. Previously we demonstrated that N1(ic) and N2(ic) could transform E1A immortalized baby rat kidney cells (RKE) in vitro. We now report direct evidence that N1(ic) must accumulate in the nucleus to induce transformation of RKE cells. In addition, we define the minimal domain of N1(ic) required to induce transformation and present evidence that transformation of RKE cells by N1(ic) is likely to be through a CBF1-independent pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.