ArticleMolecular and cellular biology2000
Multiple signals regulate GAL transcription in yeast.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 72 citations in OpenAlex.
- The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway.PLoS genetics · 2022Article
- TORC1 signaling modulates Cdk8-dependent GAL gene expression in Saccharomyces cerevisiae.Genetics · 2021Article
- Article
- Zinc oxide and silver nanoparticles toxicity in the baker's yeast, Saccharomyces cerevisiae.PloS one · 2018Article
- Genetic and Epigenetic Strategies Potentiate Gal4 Activation to Enhance Fitness in Recently Diverged Yeast Species.Current biology : CB · 2017Article
- Evaluation and application of constitutive promoters for cutinase production by Saccharomyces cerevisiae.Journal of microbiology (Seoul, Korea) · 2017Article
- Untargeted metabolomics unravels functionalities of phosphorylation sites in Saccharomyces cerevisiae.BMC systems biology · 2016Article
- Mediator tail subunits can form amyloid-like aggregates in vivo and affect stress response in yeast.Nucleic acids research · 2015Article
- CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and -independent functions in Arabidopsis.The Plant cell · 2014Article
- Cross-talk of phosphorylation and prolyl isomerization of the C-terminal domain of RNA Polymerase II.Molecules (Basel, Switzerland) · 2014Review
- Cdk8 regulates stability of the transcription factor Phd1 to control pseudohyphal differentiation of Saccharomyces cerevisiae.Molecular and cellular biology · 2012Article
- Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host.PLoS pathogens · 2012Article
- Cryptococcus neoformans mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence.PloS one · 2011Article
- Regulation of galactose metabolism through the HisK:GalR two-component system in Thermoanaerobacter tengcongensis.Journal of bacteriology · 2010Article
- Article
- A fungal family of transcriptional regulators: the zinc cluster proteins.Microbiology and molecular biology reviews : MMBR · 2006Review
- Yeast Gal4: a transcriptional paradigm revisited.EMBO reports · 2006Review
- Interaction of the Srb10 kinase with Sip4, a transcriptional activator of gluconeogenic genes in Saccharomyces cerevisiae.Molecular and cellular biology · 2001Article
- The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4.Genes & development · 2001Article
- Comparison of the proteomes of three yeast wild type strains: CEN.PK2, FY1679 and W303.Comparative and functional genomics · 2001Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gal4p activates transcription of the Saccharomyces GAL genes in response to galactose and is phosphorylated during interaction with the RNA polymerase II (Pol II) holoenzyme. One phosphorylation at S699 is necessary for full GAL induction and is mediated by Srb10p/CDK8 of the RNA Pol II holoenzyme mediator subcomplex. Gal4p S699 phosphorylation is necessary for sensitive response to inducer, and its requirement for GAL induction can be abrogated by high concentrations of galactose in strains expressing wild-type GAL2 and GAL3. Gal4p S699 phosphorylation occurs independently of Gal3p and is responsible for the long-term adaptation response observed in gal3 yeast. SRB10 and GAL3 are shown to represent parallel mechanisms for GAL gene induction. These results demonstrate that Gal4p activity is controlled by two independent signals: one that acts through Gal3p-galactose and a second that is mediated by the holoenzyme-associated cyclin-dependent kinase Srb10p. Since Srb10p is regulated independently of galactose, our results suggest a function for CDK8 in coordinating responses to specific inducers with the environment through the phosphorylation of gene-specific activators.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.