ArticleMolecular and cellular biology2000
Repression of ribosome and tRNA synthesis in secretion-defective cells is signaled by a novel branch of the cell integrity pathway.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed.
- Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus.Molecular cell · 2026Review
- Article
- Cell growth and nutrient availability control the mitotic exit signaling network in budding yeast.The Journal of cell biology · 2024Article
- Article
- Robust repression of tRNA gene transcription during stress requires protein arginine methylation.Life science alliance · 2019Article
- Sphingolipid/Pkh1/2-TORC1/Sch9 Signaling Regulates Ribosome Biogenesis in Tunicamycin-Induced Stress Response in Yeast.Genetics · 2019Article
- Glycolytic flux inThe Biochemical journal · 2019Article
- Nuclear envelope expansion in budding yeast is independent of cell growth and does not determine nuclear volume.Molecular biology of the cell · 2019Article
- Signaling to and from the RNA Polymerase III Transcription and Processing Machinery.Annual review of biochemistry · 2018Review
- A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast.Molecular biology of the cell · 2017Article
- Protein Kinase C Controls Binding of Igo/ENSA Proteins to Protein Phosphatase 2A in Budding Yeast.The Journal of biological chemistry · 2017Article
- Ribosome quality control is a central protection mechanism for yeast exposed to deoxynivalenol and trichothecin.BMC genomics · 2016Article
- Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.Genes & development · 2015Article
- Differential Phosphorylation of RNA Polymerase III and the Initiation Factor TFIIIB in Saccharomyces cerevisiae.PloS one · 2015Article
- Chromatin-dependent regulation of RNA polymerases II and III activity throughout the transcription cycle.Nucleic acids research · 2015Article
- Delayed Ras/PKA signaling augments the unfolded protein response.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- RNA polymerase I stability couples cellular growth to metal availability.Molecular cell · 2013Article
- Plasma membrane growth during the cell cycle: unsolved mysteries and recent progress.Current opinion in cell biology · 2012Review
- Phospholipid flippases: building asymmetric membranes and transport vesicles.Biochimica et biophysica acta · 2012Review
9 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
The transcription of ribosomal DNA, ribosomal protein (RP) genes, and 5S and tRNA genes by RNA polymerases (Pols) I, II, and III, respectively, is rapidly and coordinately repressed upon interruption of the secretory pathway in Saccharomyces cerevisiae. We find that repression of ribosome and tRNA synthesis in secretion-defective cells involves activation of the cell integrity pathway. Transcriptional repression requires the upstream components of this pathway, including the Wsc family of putative plasma membrane sensors and protein kinase C (PKC), but not the downstream Bck1-Mkk1/2-Slt2 mitogen-activated protein kinase cascade. These findings reveal a novel PKC effector pathway that controls more than 85% of nuclear transcription. It is proposed that the coordination of ribosome and tRNA synthesis with cell growth may be achieved, in part, by monitoring the turgor pressure of the cell.
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