ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Cell contact regulates fate choice by cortical stem cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
38 citing papers in PubMed, 201 citations in OpenAlex.
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- Towards clinical application of tissue engineering for erectile penile regeneration.Nature reviews. Urology · 2019Review
- Bioengineering an Artificial Human Blood⁻Brain Barrier in Rodents.Bioengineering (Basel, Switzerland) · 2019Article
- A comparison of the stem cell characteristics of murine tenocytes and tendon-derived stem cells.BMC musculoskeletal disorders · 2018Article
- Grafted Neural Stem Cells Show Lesion-Specific Migration in Radiation-Injured Rat Brains.RSC advances · 2018Article
- Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation.Biomaterials · 2016Article
- Specific Preferences in Lineage Choice and Phenotypic Plasticity of Glioma Stem Cells Under BMP4 and Noggin Influence.Brain pathology (Zurich, Switzerland) · 2016Article
- Vascular Transdifferentiation in the CNS: A Focus on Neural and Glioblastoma Stem-Like Cells.Stem cells international · 2016Review
- Mass spectrometry-based quantitative proteomic profiling of human pancreatic and hepatic stellate cell lines.Genomics, proteomics & bioinformatics · 2013Article
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- Biomimetic three-dimensional microenvironment for controlling stem cell fate.Interface focus · 2011Article
- Microprinted feeder cells guide embryonic stem cell fate.Biotechnology and bioengineering · 2011Article
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- Directed stem cell differentiation: the role of physical forces.Cell communication & adhesion · 2010Review
- A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry.Brain : a journal of neurology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell fate is determined by intrinsic programs and external cues, such as soluble signals and cell-cell contact. Previous studies have demonstrated the roles of soluble factors in the proliferation and differentiation of cortical stem cells and cell-cell contact in maintaining stem cells in a proliferative state. In the present study, we focused on the effect of cell-cell interaction on cell-fate determination. We found that density could exert a strong influence on the cell-type composition when cortical stem cells differentiate. Multipotent stem cells, which normally gave rise to neurons, astrocytes, and oligodendrocytes under high-density culture condition, differentiated almost exclusively into smooth muscle at low density. Clonal analysis indicated that smooth muscle and astrocytes were derived from a common precursor and that the density effect on cell types used an instructive mechanism on the choice of fate rather than an effect of selective survival and/or proliferation. This instructive mechanism depended on the local and not the average density of the cells. This local signal could be mimicked by membrane extract. These findings demonstrate the importance of membrane-bound signals in specifying lineage and provide the first evidence for a short-range regulatory mechanism in cortical stem cell differentiation.
Indexed as
Identifiers
10804214PMC6772699W1504875278What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.