ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Protein phosphatase-1 regulation in the induction of long-term potentiation: heterogeneous molecular mechanisms.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed.
- A biochemical description of postsynaptic plasticity-with timescales ranging from milliseconds to seconds.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Regulation of Synaptic Transmission and Plasticity by Protein Phosphatase 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Protein Phosphatase 1 Inhibitor-1 Mediates the cAMP-Dependent Stimulation of the Renal NaCl Cotransporter.Journal of the American Society of Nephrology : JASN · 2019Article
- cAMP regulation of protein phosphatases PP1 and PP2A in brain.Biochimica et biophysica acta. Molecular cell research · 2019Review
- Functions and therapeutic potential of protein phosphatase 1: Insights from mouse genetics.Biochimica et biophysica acta. Molecular cell research · 2019Review
- Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Hypermethylation of Synphilin-1, Alpha-Synuclein-Interacting Protein (SNCAIP) Gene in the Cerebral Cortex of Patients with Sporadic Parkinson's Disease.Brain sciences · 2017Article
- I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model.International journal of cardiology. Heart & vasculature · 2015Article
- Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility.European journal of heart failure · 2015Article
- Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension.Journal of the American Society of Nephrology : JASN · 2014Article
- Article
- Synaptic Signaling in Learning and Memory.Cold Spring Harbor perspectives in biology · 2013Review
- Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5.The Journal of cell biology · 2013Article
- An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex.Neuroscience · 2010Article
- Beta-adrenergic stimulation and myocardial function in the failing heart.Heart failure reviews · 2009Review
- Anterior thalamic lesions produce chronic and profuse transcriptional de-regulation in retrosplenial cortex: A model of retrosplenial hypoactivity and covert pathology.Thalamus & related systems · 2008Article
- Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase.Progress in brain research · 2008Review
- Learning-induced glutamate receptor phosphorylation resembles that induced by long term potentiation.The Journal of biological chemistry · 2007Article
- Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5.The Journal of biological chemistry · 2007Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Protein phosphatase inhibitor-1 (I-1) has been proposed as a regulatory element in the signal transduction cascade that couples postsynaptic calcium influx to long-term changes in synaptic strength. We have evaluated this model using mice lacking I-1. Recordings made in slices prepared from mutant animals and also in anesthetized mutant animals indicated that long-term potentiation (LTP) is deficient at perforant path-dentate granule cell synapses. In vitro, this deficit was restricted to synapses of the lateral perforant path. LTP at Schaffer collateral-CA1 pyramidal cell synapses remained normal. Thus, protein phosphatase-1-mediated regulation of NMDA receptor-dependent synaptic plasticity involves heterogeneous molecular mechanisms, in both different dendritic subregions and different neuronal subtypes. Examination of the performance of I-1 mutants in spatial learning tests indicated that intact LTP at lateral perforant path-granule cell synapses is either redundant or is not involved in this form of learning.
Indexed as
Identifiers
10804194PMC6772695What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.