ArticleJournal of virology2000
Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- CD4The American journal of pathology · 2020Article
- Tetherin promotes the innate and adaptive cell-mediated immune response against retrovirus infection in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Elimination of friend retrovirus in the absence of CD8+ T cells.Journal of virology · 2014Article
- A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo.PLoS pathogens · 2012Article
- Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions In Vivo.Journal of virology · 2011Article
- CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection.Journal of virology · 2005Article
- Reduction of retrovirus-induced immunosuppression by in vivo modulation of T cells during acute infection.Journal of virology · 2004Article
- Preinfection treatment of resistant mice with CpG oligodeoxynucleotides renders them susceptible to friend retrovirus-induced leukemia.Journal of virology · 2003Article
- Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs.Journal of virology · 2002Article
- Novel role of CD8(+) T cells and major histocompatibility complex class I genes in the generation of protective CD4(+) Th1 responses during retrovirus infection in mice.Journal of virology · 2002Article
- Temporal effects of gamma interferon deficiency on the course of Friend retrovirus infection in mice.Journal of virology · 2002Article
- Essential roles for CD8+ T cells and gamma interferon in protection of mice against retrovirus-induced immunosuppression.Journal of virology · 2002Article
- Critical roles of PPAR beta/delta in keratinocyte response to inflammation.Genes & development · 2001Article
- Role of interleukin-4 (IL-4), IL-12, and gamma interferon in primary and vaccine-primed immune responses to Friend retrovirus infection.Journal of virology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Recovery from leukemia induced by Friend virus complex (FV) requires strong CD4(+) helper, CD8(+) cytotoxic T-lymphocyte, and B-cell responses. The development of these immune responses is dependent on the major histocompatibility complex (MHC) (H-2) genotype of the mouse. In H-2(b/b) mice, which spontaneously recover from FV-induced erythroleukemia, neutralization of gamma interferon (IFN-gamma) in vivo inhibited recovery, which indicated that IFN-gamma was a necessary component of the immune response to FV. Furthermore, in H-2(b/b) mice, high numbers of IFN-gamma-producing cells were detected after FV infection, whereas in H-2(a/b) mice, which have a low-recovery phenotype, only low numbers of IFN-gamma-producing cells were detected. Similarly, H-2(bm14/b) mice, which cannot recover from FV infection due to a point mutation in one allele of the H-2D(b) gene, also had low numbers of IFN-gamma-producing T cells. Surprisingly, this effect was observed for both CD8(+) and CD4(+) T cells. These findings reveal a novel influence of MHC class I genes on CD4(+) T-cell responses to viral infection. Furthermore, the influence of MHC class I genotype on the generation of both IFN-gamma-producing CD4(+) and CD8(+) T cells helps explain the major impact of the H-2D gene on recovery from FV disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.