ArticleJournal of virology2000
Activation of divergent neuronal cell death pathways in different target cell populations during neuroadapted sindbis virus infection of mice.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- Neurotropic alphavirus infection induces PARP-1 hyperactivation-mediated energy collapse in motor neurons.Journal of virology · 2026Article
- Article
- Production of Noncapped Genomic RNAs Is Critical to Sindbis Virus Disease and Pathogenicity.mBio · 2020Article
- The NF-κB/leukemia inhibitory factor/STAT3 signaling pathway in antibody-mediated suppression of Sindbis virus replication in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Immunopathogenesis of alphaviruses.Advances in virus research · 2020Article
- Germ Line IgM Is Sufficient, but Not Required, for Antibody-Mediated Alphavirus Clearance from the Central Nervous System.Journal of virology · 2018Article
- Article
- Alphavirus Encephalomyelitis: Mechanisms and Approaches to Prevention of Neuronal Damage.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Distinct Immune Responses in Resistant and Susceptible Strains of Mice during Neurovirulent Alphavirus Encephalomyelitis.Journal of virology · 2015Article
- Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine.Journal of neurovirology · 2015Article
- Virus infection, antiviral immunity, and autoimmunity.Immunological reviews · 2013Review
- The role of innate versus adaptive immune responses in a mouse model of O'nyong-nyong virus infection.The American journal of tropical medicine and hygiene · 2013Article
- Review
- Complexity of the microglial activation pathways that drive innate host responses during lethal alphavirus encephalitis in mice.ASN neuro · 2012Article
- Novel inhibitors of neurotropic alphavirus replication that improve host survival in a mouse model of acute viral encephalitis.Journal of medicinal chemistry · 2012Article
- Neuromuscular manifestations of west nile virus infection.Frontiers in neurology · 2012Article
- Viral encephalomyelitis.PLoS pathogens · 2011Article
- Recovery from viral encephalomyelitis: immune-mediated noncytolytic virus clearance from neurons.Immunologic research · 2010Review
- Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection.Journal of neuropathology and experimental neurology · 2009Article
- Noncytolytic clearance of sindbis virus infection from neurons by gamma interferon is dependent on Jak/STAT signaling.Journal of virology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Infection of adult mice with neuroadapted Sindbis virus (NSV) results in a severe encephalomyelitis accompanied by prominent hindlimb paralysis. We find that the onset of paralysis parallels morphologic changes in motor neuron cell bodies in the lumbar spinal cord and in motor neuron axons in ventral nerve roots, many of which are eventually lost over time. However, unlike NSV-induced neuronal cell death found in the brain of infected animals, the loss of motor neurons does not appear to be apoptotic, as judged by morphologic and biochemical criteria. This may be explained in part by the lack of detectable caspase-3 expression in these cells.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.