ArticleJournal of virology2000
Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 71 citations in OpenAlex.
- Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir.Journal of virology · 2006Trial
- Role of the CARD8 inflammasome in HIV pathogenesis.Cell insight · 2024Review
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- Regulation of ABC Drug Efflux Transporters in Human T-Cells Exposed to an HIV Pseudotype.Frontiers in pharmacology · 2021Article
- An Evolutionary Model of Progression to AIDS.Microorganisms · 2020Article
- HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis.Cell reports · 2019Article
- Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Histoculture and Infection with HIV of Functional Human Lymphoid Tissue on GelfoamMethods in molecular biology (Clifton, N.J.) · 2018Article
- Modeling the Mechanisms by Which HIV-Associated Immunosuppression Influences HPV Persistence at the Oral Mucosa.PloS one · 2017Article
- Human Immunodeficiency Virus Immune Cell Receptors, Coreceptors, and Cofactors: Implications for Prevention and Treatment.AIDS patient care and STDs · 2016Review
- HIV-1 vaginal transmission: cell-free or cell-associated virus?American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Review
- CD4(+) T-cell depletion in HIV infection: mechanisms of immunological failure.Immunological reviews · 2013Review
- Hybrid approach for predicting coreceptor used by HIV-1 from its V3 loop amino acid sequence.PloS one · 2013Article
- Cervico-vaginal tissue ex vivo as a model to study early events in HIV-1 infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2011Article
- Caveolin-1 modulates HIV-1 envelope-induced bystander apoptosis through gp41.Journal of virology · 2010Article
- Lack of in vivo compartmentalization among HIV-1 infected naïve and memory CD4+ T cell subsets.Virology · 2009Article
- Selective expression of human immunodeficiency virus Nef in specific immune cell populations of transgenic mice is associated with distinct AIDS-like phenotypes.Journal of virology · 2009Article
- Relationship between HIV coreceptor tropism and disease progression in persons with untreated chronic HIV infection.Journal of acquired immune deficiency syndromes (1999) · 2009Article
- Use of human tissue explants to study human infectious agents.Nature protocols · 2009Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The present study sought to determine how usage of coreceptors by human immunodeficiency virus type 1 dictates cell tropism and depletion of CD4(+) T cells in human lymphoid tissues cultured ex vivo. We found that coreceptor preferences control the marked, preferential depletion of coreceptor-expressing CD4(+) lymphocytes. In addition, there was a strong, but not absolute, preference shown by CXCR4-using strains for lymphocytes and by CCR5-using strains for macrophages.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.