ArticleJournal of virology2000
Low dynamic state of viral competition in a chronic avian hepadnavirus infection.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 64 citations in OpenAlex.
- Mapping the Heterogeneity of Histone Modifications on Hepatitis B Virus DNA Using Liver Needle Biopsies Obtained from Chronically Infected Patients.Journal of virology · 2019Trial
- Article
- Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Tenofovir has inferior efficacy in adefovir-experienced chronic hepatitis B patients compared to nucleos(t)ide-naïve patients.Clinical and molecular hepatology · 2017Article
- Combinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice.Scientific reports · 2015Article
- Duck Hepatitis B Virus cccDNA Amplification Efficiency in Natural Infection Is Regulated by Virus Secretion Efficiency.PloS one · 2015Article
- A high level of mutation tolerance in the multifunctional sequence encoding the RNA encapsidation signal of an avian hepatitis B virus and slow evolution rate revealed by in vivo infection.Journal of virology · 2011Article
- A perspective on modelling hepatitis C virus infection.Journal of viral hepatitis · 2010Review
- Fitness and infectivity of drug-resistant and cross-resistant hepatitis B virus mutants: why and how is it studied?Antiviral therapy · 2010Review
- Antiviral resistance and hepatitis B therapy.Hepatology (Baltimore, Md.) · 2009Article
- Hepatitis B virus (HBV)-specific short hairpin RNA is capable of reducing the formation of HBV covalently closed circular (CCC) DNA but has no effect on established CCC DNA in vitro.The Journal of general virology · 2009Article
- Immune selection during chronic hepadnavirus infection.Hepatology international · 2008Article
- The sequence of the RNA primer and the DNA template influence the initiation of plus-strand DNA synthesis in hepatitis B virus.Journal of molecular biology · 2007Article
- Dynamics of hepatitis B virus clearance in chimpanzees.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Article
- Age-related differences in amplification of covalently closed circular DNA at early times after duck hepatitis B virus infection of ducks.Journal of virology · 2005Article
- Superinfection exclusion in duck hepatitis B virus infection is mediated by the large surface antigen.Journal of virology · 2004Article
- Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Rapid production of neutralizing antibody leads to transient hepadnavirus infection.Journal of virology · 2004Article
- The conformation of the 3' end of the minus-strand DNA makes multiple contributions to template switches during plus-strand DNA synthesis of duck hepatitis B virus.Journal of virology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The dynamic state of infection of 11 ducks with the duck hepatitis B virus was investigated. Chronic infections were established in newly hatched ducklings by inoculation with a mixture of wild-type virus and a mutant virus with a partial replication defect. As expected, the wild-type virus was rapidly enriched in the virus population during the spread of infection. Enrichment thereafter was correlated with normal growth of the liver, with the average mutant-to-wild-type ratio stabilizing for at least 2 months beyond the time at which the liver mass stabilized. Using experimentally determined growth rates for the mutant and wild-type viruses, we estimated that after the spread of infection, competition between the two virus strains was limited by the amount of replication required to infect new hepatocytes in the growing livers. The results suggest that, in a chronically infected liver, the selection of variants with a replication rate advantage is inefficient and that the emergence of such variants would depend on induced liver cell turnover, such as that occurring during chronic hepatitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.