Evidence map›Paper›PMID 10796642›Full record

SynthesisThe Cochrane database of systematic reviews2000

Isoniazid for preventing tuberculosis in non-HIV infected persons.

M J Smieja, C A Marchetti, D J Cook, F M Smaill

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Cochrane database of systematic reviews, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03028129 (Primary Prophylaxis for Prevention of TB in Prison's Populations), which is not on this map. Cited by 182 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
182citing papers in PubMed, 14 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03028129 phase4terminatednot on this mapstarted 2017, after this paper: background citation

Primary Prophylaxis for Prevention of TB in Prison's Populations

TypeinterventionalSponsorFederal University of Mato GrossoRan2017 to 2019Enrolled467ConditionsTuberculosis, Pulmonary, Antibiotic ProphylaxisArmsIsoniazid 900 milligrams, Placebo
3 · Its place in the literature

Who cites it

182 citing papers in PubMed, 14 syntheses or guidelines pooled it, 441 citations in OpenAlex.

  1. Pooled it
  2. Effectiveness of interventions for reducing TB incidence in countries with low TB incidence: a systematic review of reviews.European respiratory review : an official journal of the European Respiratory Society · 2019
    Pooled it
  3. Isoniazid for preventing tuberculosis in HIV-infected children.The Cochrane database of systematic reviews · 2017
    Pooled it
  4. Pooled it
  5. Directly observed therapy for treating tuberculosis.The Cochrane database of systematic reviews · 2015
    Pooled it
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  7. Pooled it
  8. Pooled it
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  10. Tuberculosis (HIV-negative people).BMJ clinical evidence · 2011
    Pooled it
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  12. Treatment of latent tuberculosis infection in HIV infected persons.The Cochrane database of systematic reviews · 2010
    Pooled it
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122 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

M J SmiejaLaboratory Medicine, McMaster University Medical Centre, Microbiology HSC- 2N29, 1200 Main Street West, Hamilton, Ontario, Canada, L8N 3Z5. smiejam@fhs.csu.mcmaster.ca
C A Marchetti
D J Cook
F M Smaill
McMaster University · CACredit Valley Hospital · CASt. Joseph’s Healthcare Hamilton · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough isoniazid (INH) is commonly used for treating tuberculosis (TB), it is also effective as preventive therapy.

objectivesThe objective of this review was to estimate the effect of 6 and 12 month courses of INH for preventing TB in HIV-negative people at increased risk of developing active TB. SEARCH STRATEGY: We searched the Cochrane Infectious Diseases Group trials register, the Cochrane Controlled Trials Register, Medline, Embase and reference lists of articles. We hand-searched Science Citation Index and Index Medicus. SELECTION CRITERIA: Randomised trials of INH preventive therapy for 6 months or more compared with placebo. Follow-up for a minimum of 2 years. Trials enrolling patients with current or previously treated active TB, or with known HIV infection, were excluded. Criteria were applied by two reviewers independently. DATA COLLECTION AND ANALYSIS: Trial quality was assessed by two reviewers independently, and data extracted by one reviewer using a standardized extraction form. MAIN

resultsEleven trials involving 73,375 patients were included. Trials were generally of high quality. Treatment with INH resulted in a relative risk (RR) of developing active TB of 0.40, (95% confidence interval ¿CI¿ 0.31 to 0.52), over two years or longer. There was no significant difference between 6 and 12 month courses (RR of 0.44, 95% CI 0.27 to 0.73 for six months, and 0.38, 95% CI 0.28 to 0.50 for 12 months). Preventive therapy reduced deaths from TB, but this effect was not seen for all cause mortality. INH was associated with hepatotoxicity in 0.36% of people on 6 months treatment and in 0.52% of people treated for 12 months. REVIEWER'S

conclusionsIsoniazid is effective for the prevention of active TB in diverse at-risk patients, and six and 12 month regimens have a similar effect.

Indexed as

HIV InfectionsAntitubercular AgentsHumansIsoniazidTuberculosis, PulmonaryAntitubercular AgentsIsoniazid

Identifiers

PMID10796642
PMCPMC6532737
OpenAlexW1930781376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.