SynthesisThe Cochrane database of systematic reviews2000
Bronchodilators for bronchiolitis.
Synthesis in The Cochrane database of systematic reviews, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Short acting beta agonists for recurrent wheeze in children under 2 years of age.The Cochrane database of systematic reviews · 2002Pooled it
- Nebulized Magnesium Sulfate in Acute Bronchiolitis: A Randomized Controlled Trial.Indian journal of pediatrics · 2015Trial
- A prospective randomised trial comparing nasogastric with intravenous hydration in children with bronchiolitis (protocol): the comparative rehydration in bronchiolitis study (CRIB).BMC pediatrics · 2010Trial
- Computerized acoustic assessment of treatment efficacy of nebulized epinephrine and albuterol in RSV bronchiolitis.BMC pediatrics · 2007Trial
- Racemic epinephrine compared to salbutamol in hospitalized young children with bronchiolitis; a randomized controlled clinical trial [ISRCTN46561076].BMC pediatrics · 2005Trial
- Saline nebulizers in treatment of bronchiolitis.Journal of family medicine and primary care · 2024Article
- Lung ultrasound in infants with bronchiolitis.BMC pulmonary medicine · 2019Article
- Therapeutic effects of Ventolin versus hypertonic saline 3% for acute bronchiolitis in children.Medical journal of the Islamic Republic of Iran · 2015Article
- Effect of combined dexamethasone therapy with nebulized r-epinephrine or salbutamol in infants with bronchiolitis: A randomized, double-blind, controlled trial.Avicenna journal of medicine · 2014Article
- Clinical profile of bronchiolitis in infants younger than 90 days in Saudi Arabia.Journal of emergencies, trauma, and shock · 2014Article
- Respiratory syncytial virus: current and emerging treatment options.ClinicoEconomics and outcomes research : CEOR · 2014Review
- Acute bronchiolitis in a paediatric emergency department of Northern Greece. Comparisons between two decades.Archives of medical science : AMS · 2012Article
- Comparison of epinephrine to salbutamol in acute bronchiolitis.Iranian journal of pediatrics · 2012Article
- Severe childhood respiratory viral infections.Advances in pediatrics · 2009Review
- Epidemiologic, experimental, and clinical links between respiratory syncytial virus infection and asthma.Clinical microbiology reviews · 2008Review
- Challenges to improving case management of childhood pneumonia at health facilities in resource-limited settings.Bulletin of the World Health Organization · 2008Review
- Bronchiolitis.Canadian family physician Medecin de famille canadien · 2008Review
- Treatment in the pediatric emergency department is evidence based: a retrospective analysis.BMC pediatrics · 2006Article
- Chest radiography in children aged 2-59 months diagnosed with non-severe pneumonia as defined by World Health Organization: descriptive multicentre study in Pakistan.BMJ (Clinical research ed.) · 2006Article
- Pathogenesis of respiratory syncytial virus infection in the murine model.Proceedings of the American Thoracic Society · 2005Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBronchiolitis is an acute, highly communicable lower respiratory tract infection. Bronchodilators are commonly used in the management of bronchiolitis in North America, but not in the United Kingdom. The objective of this review was to assess the effects of bronchodilators for bronchiolitis. SEARCH STRATEGY: We searched MEDLINE, EMBASE, Reference Update, reference lists of articles, and the files of two of the authors up to June 1998. SELECTION CRITERIA: Randomised trials comparing bronchodilators with placebo in the treatment of bronchiolitis. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed trial quality and extracted data. Unpublished data were requested from authors when necessary. MAIN
resultsIn eight trials with 394 children, 46% demonstrated an improved clinical score with bronchodilators compared to 75% with placebo (odds ratio for no improvement 0.29, 95% confidence interval 0.19 to 0.45). However, the inclusion of studies that enrolled people with recurrent wheezes may have biased these results in favour of bronchodilators. Bronchodilator recipients did not show improvement in measures of oxygenation, the rate of hospitalisation (18% versus 26%, odds ratio 0.70, 95% confidence interval 0.36 to 1.35) or duration of hospitalisation (weighted mean difference 0.12, 95% confidence interval -0.3 to 0.5). REVIEWER'S
conclusionsBronchodilators produce modest short-term improvement in clinical scores. This small benefit must be weighed against the costs of these agents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.