SynthesisThe Cochrane database of systematic reviews2000
Plasma volume expansion for treatment of women with pre-eclampsia.
Synthesis in The Cochrane database of systematic reviews, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 12 syntheses or guidelines pooled it.
- Prenatal metal(loid) exposure and preterm birth: a systematic review of the epidemiologic evidence.Journal of exposure science & environmental epidemiology · 2025Pooled it
- Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation.The Cochrane database of systematic reviews · 2018Pooled it
- Antenatal interventions to reduce preterm birth: an overview of Cochrane Systematic Reviews.BMC research notes · 2014Pooled it
- Drugs for treatment of very high blood pressure during pregnancy.The Cochrane database of systematic reviews · 2013Pooled it
- Quantifying the fall in mortality associated with interventions related to hypertensive diseases of pregnancy.BMC public health · 2011Pooled it
- Pre-eclampsia, eclampsia, and hypertension.BMJ clinical evidence · 2011Pooled it
- Magnesium sulphate versus diazepam for eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Magnesium sulphate versus phenytoin for eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Magnesium sulphate versus lytic cocktail for eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- The diagnosis and treatment of hypertensive disorders of pregnancy: new findings for antenatal and inpatient care.Deutsches Arzteblatt international · 2009Pooled it
- Plasma volume expansion for treatment of women with pre-eclampsia.The Cochrane database of systematic reviews · 2000Pooled it
- Norepinephrine versus colloid for preventing spinal anesthesia-induced hypotension and its impact on intracranial pressure in preeclamptic parturients: a randomized double-blind controlled trial.BMC pregnancy and childbirth · 2026Trial
- Echocardiographic assessment and critical care management of peri-partum women with unexpected left ventricular failure.Journal of the Intensive Care Society · 2022Review
- [Special pathologies of pregnant patients in intensive care medicine].Der Anaesthesist · 2021Article
- Research Recommendations From the National Institutes of Health Workshop on Predicting, Preventing, and Treating Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2019Review
- Preeclampsia: Vascular Pathophysiological Mechanism and the Basis for Early Diagnosis and Treatment.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2016Article
- Diagnosis and Treatment of Hypertensive Pregnancy Disorders. Guideline of DGGG (S1-Level, AWMF Registry No. 015/018, December 2013).Geburtshilfe und Frauenheilkunde · 2015Article
- Maternal mortality secondary to acute respiratory failure in Colombia: a population-based analysis.Lung · 2015Article
- Postpartum acute renal failure: a multicenter study of risk factors in patients admitted to ICU.Annals of intensive care · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlasma volume is reduced amongst women with pre-eclampsia. This association has led to the suggestion that expanding the plasma volume might improve maternal and uteroplacental circulation, and so potentially improve outcome for both the woman and her baby.
objectivesThe aim of this review was to assess the effects of plasma volume expansion for the treatment of women with pre-eclampsia. SEARCH STRATEGY: The register of trials maintained by the Cochrane Pregnancy and Childbirth Group, and the Cochrane Controlled Trials Register Issue 1 1999 were searched for trials meeting the selection criteria. SELECTION CRITERIA: Randomised trials were included. Quasi-random designs were excluded. Participants were women with hypertension during pregnancy, with or without proteinuria. Women who were postpartum at trial entry were excluded. Interventions were any comparison of plasma volume expansion with no expansion, or of one plasma volume expander with another. DATA COLLECTION AND ANALYSIS: Data were extracted independently by two reviewers. Discrepancies were resolved by discussion. There was no blinding of authorship or results. MAIN
resultsThree trials involving 61 women were included in this review. All compared a colloid solution with no plasma volume expansion. For every outcome reported, the confidence intervals are very wide and cross the no effect line. REVIEWER'S
conclusionsThere is insufficient evidence for any reliable estimates of the effects of plasma volume expansion for women with pre-eclampsia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.