SynthesisThe Cochrane database of systematic reviews2000
Interventions for treating bacterial vaginosis in pregnancy.
Synthesis in The Cochrane database of systematic reviews, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 195 citations in OpenAlex.
- Antibiotic treatment of bacterial vaginosis to prevent preterm delivery: Systematic review and individual participant data meta-analysis.Paediatric and perinatal epidemiology · 2023Pooled it
- Antibiotics for treating bacterial vaginosis in pregnancy.The Cochrane database of systematic reviews · 2013Pooled it
- Antibiotics for treating bacterial vaginosis in pregnancy.The Cochrane database of systematic reviews · 2007Pooled it
- Prospective randomised controlled trial of an infection screening programme to reduce the rate of preterm delivery.BMJ (Clinical research ed.) · 2004Trial
- Vaginal microbiome and preterm birth: Composition, mechanisms and microbiota‑directed therapies (Review).International journal of molecular medicine · 2025Review
- Total and Free 25-Hydroxy-Vitamin D and Bacterial Vaginosis in Pregnant African American Women.Infectious diseases in obstetrics and gynecology · 2019Article
- Bacterial and cytokine mixtures predict the length of gestation and are associated with miRNA expression in the cervix.Epigenomics · 2017Article
- Recurrent spontaneous miscarriage is still a challenging diagnostic and therapeutic quagmire.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2015Review
- Maternal vitamin D, folate, and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy.Infectious diseases in obstetrics and gynecology · 2011Article
- Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy.The Journal of nutrition · 2009Article
- Prevalence of and factors associated with reproductive tract infections among pregnant women in ten communes in Nghe An Province, Vietnam.Journal of epidemiology · 2005Article
- Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort study.Sao Paulo medical journal = Revista paulista de medicina · 2005Article
- Current perspectives on the prevention and management of chronic lung disease in preterm infants.Paediatric drugs · 2003Review
- Bacterial vaginosis during pregnancy. Should we screen for and treat it?Canadian family physician Medecin de famille canadien · 2002Article
Corrections and comments
- Updated by
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacterial vaginosis has been associated with poor perinatal outcome. Since the infections are amenable to treatment, identification during pregnancy and treatment may reduce the risk of preterm birth and its consequences.
objectivesThe objective of this review was to assess the effects of antibiotic treatment of bacterial vaginosis in pregnancy. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register. SELECTION CRITERIA: Randomised trials comparing one antibiotic regimen with placebo or no treatment, or which compare two or more alternative antibiotic regimens in pregnant women with bacterial vaginosis. DATA COLLECTION AND ANALYSIS: Trial quality assessments and data extraction were done independently by three reviewers. Study authors were contacted for additional information. MAIN
resultsFive trials involving 1504 women were included. These trials were of good quality. Antibiotic therapy was highly effective at eradicating infection during pregnancy as judged by 'test-of-cure' following therapy (odds ratio 0.22, 95% confidence interval 0.17 to 0.27). The effect of treating bacterial vaginosis during pregnancy showed a trend to less births before 37 weeks gestation (odds ratio 0.78, 95% confidence interval 0.60 to 1.02). The prevention of preterm birth less than 37 weeks gestation was most marked in the subgroup of women with a previous preterm birth (odds ratio 0.37, 95% confidence interval 0.23 to 0. 60). REVIEWER'S
conclusionsThe current evidence does not support screening and treating all pregnant women for bacterial vaginosis to prevent preterm birth and its consequences. For women with a history of a previous preterm birth there is some suggestion that detection and treatment of bacterial vaginosis early in pregnancy may prevent a proportion of these women having a further preterm birth. It is not known whether this is associated with an improvement in neonatal well-being.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.