ArticleArchives of disease in childhood. Fetal and neonatal edition2000
Anoxic ATP depletion in neonatal mice brainstem is prevented by creatine supplementation.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 53 citations in OpenAlex.
- Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- PreclinicalMagnetic resonance in medicine · 2026Article
- COScientific reports · 2025Article
- Prophylactic Fetal Creatine Supplementation Improves Post-Asphyxial EEG Recovery and Reduces Seizures in Fetal Sheep: Implications for Hypoxic-Ischemic Encephalopathy.Annals of neurology · 2025Article
- Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration.Neuron · 2022Review
- A review of creatine supplementation in age-related diseases: more than a supplement for athletes.F1000Research · 2014Review
- Respiratory related control of hypoglossal motoneurons--knowing what we do not know.Respiratory physiology & neurobiology · 2011Review
- Mitochondrial approaches for neuroprotection.Annals of the New York Academy of Sciences · 2008Review
- The creatine kinase/creatine connection to Alzheimer's disease: CK-inactivation, APP-CK complexes and focal creatine deposits.Journal of biomedicine & biotechnology · 2006Article
- Pharmacokinetics of the dietary supplement creatine.Clinical pharmacokinetics · 2003Review
- Creatine and the creatine transporter: a review.Molecular and cellular biochemistry · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSufficient ATP concentrations maintain physiological processes and protect tissue from hypoxic damage. With decreasing oxygen concentration, ATP synthesis relies increasingly on the presence of phosphocreatine.
aimThe effect of exogenously applied creatine on phosphocreatine and ATP concentrations was studied under control and anoxic conditions.
methodsPregnant mice were fed orally with creatine monohydrate (2 g/kg body weight/day). Brainstem slices from these mice pups were compared with those from pups of non-creatine supplemented pregnant mice. Measurements were performed under normoxic and anoxic conditions. In addition, brainstem slices from non-creatine treated mice pups were incubated for 3 hours in control artificial cerebrospinal fluid (CSF) (n = 10) or in artificial CSF containing 200 microM creatine (n = 10). ATP and phosphocreatine contents were determined enzymatically in single brainstem slices.
resultsATP concentrations were in the same range in all preparations. However, there was a significant increase of phosphocreatine in the brainstems from pups of creatine fed mice when compared with the brainstems of pups from non-creatine treated mice or in non-incubated brainstems of control animals. After 30 minutes anoxia, ATP as well as phosphocreatine concentrations remained significantly higher in creatine pretreated slices compared with controls.
conclusionThe data indicate that exogenous application of creatine is effective in neuroprotection.
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