ArticleThe Biochemical journal2000
Identification and expression analysis of leptin-regulated immediate early response and late target genes.
Article in The Biochemical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- From leptin to lasers: the past and present of mouse models of obesity.Expert opinion on drug discovery · 2021Article
- High accuracy gene expression profiling of sorted cell subpopulations from breast cancer PDX model tissue.PloS one · 2020Article
- The Leptin Receptor Complex: Heavier Than Expected?Frontiers in endocrinology · 2017Review
- IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer.Cancer research · 2015Article
- Immunoreactivities of PPARγ2, leptin and leptin receptor in oviduct of Chinese brown frog during breeding period and pre-hibernation.European journal of histochemistry : EJH · 2014Article
- Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals.Endocrine reviews · 2013Review
- Cell signals influencing hepatic fibrosis.International journal of hepatology · 2012Article
- Different physiology of interferon-α/-γ in models of liver regeneration in the rat.Histochemistry and cell biology · 2011Article
- Metallothionein and the biology of aging.Ageing research reviews · 2011Review
- The Cdk5/p35 kinases modulate leptin-induced STAT3 signaling.Journal of molecular neuroscience : MN · 2009Article
- Genes regulated by caloric restriction have unique roles within transcriptional networks.Mechanisms of ageing and development · 2008Article
- Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Transcriptional profiling of murine organ genes in response to infection with Bacillus anthracis Ames spores.Microbial pathogenesis · 2008Article
- Leptin regulates chondrogenic differentiation in ATDC5 cell-line through JAK/STAT and MAPK pathways.Endocrine · 2007Article
- Leptin induces inflammation-related genes in RINm5F insulinoma cells.BMC molecular biology · 2007Article
- Specific expression of annexin A8 in adult murine stratified epithelia.Journal of molecular histology · 2006Article
- Differential regulation of polo-like kinase 1, 2, 3, and 4 gene expression in mammalian cells and tissues.Oncogene · 2005Review
- STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers.The American journal of pathology · 2002Article
- A mediator role for metallothionein in tumor necrosis factor-induced lethal shock.The Journal of experimental medicine · 2001Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using PC12 cells as an in vitro model system, we have identified a series of transcripts induced through activation of the leptin receptor. On the basis of kinetic studies, two distinct gene sets could be discerned: signal transducer and activator of transciption-3 (STAT-3), suppressor of cytokine signalling-3 (SOCS-3), MT-II (metallothionein-II), the serine/threonine kinase fibroblast-growth-factor-inducible kinase (Fnk) and modulator recognition factor (MRF-1), which are immediate early response genes, and pancreatitis-associated protein I (PAP I), squalene epoxidase, uridine diphosphate glucuronosyltransferase and annexin VIII, which are late induced target genes. At late time points a strong co-stimulation with beta-nerve growth factor or with the adenylate cyclase activator forskolin was observed. To assess the validity of the PC12-cell model system, we examined the effect of leptin administration on the gene transcription of STAT-3, MT-II, Fnk and PAP I in vivo. Leptin treatment of leptin-deficient ob/ob mice increased the STAT-3, SOCS-3, MT-II and Fnk mRNA, and MT-I protein levels in liver, whereas, in jejunum, expression of PAP I mRNA was down-regulated. Furthermore, administration of leptin to starved wild-type mice enhanced the expression of MT-II and Fnk mRNA in liver, but decreased MT-II and PAP I mRNA expression in jejunum. These findings may help to explain the obese phenotype observed in some colonies of MT-I- and MT-II-null mice and/or the observation that leptin protects against tumour-necrosis-factor toxicity in vivo.
Indexed as
Identifiers
10794713PMC1221035W1964181541What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.