ArticlePlant molecular biology2000
Molecular cloning and expression analysis of the mevalonate kinase gene from Arabidopsis thaliana.
Article in Plant molecular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Mevalonate kinase represses anthocyanin biosynthesis via sucrose transporters and gibberellin synthesis pathways in arabidopsis.Plant cell reports · 2026Article
- Biofortified Calcium Phosphate Nanoparticles Elicit Secondary Metabolite Production in Carob Callus via Biosynthetic Pathway Activation.Plants (Basel, Switzerland) · 2025Article
- Full-length transcriptome profiling ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Activation of the plant mevalonate pathway by extracellular ATP.Nature communications · 2022Article
- ComparativeFrontiers in genetics · 2022Article
- Cloning and expression analysis of mevalonate kinase and phosphomevalonate kinase genes associated with the MVA pathway in Santalum album.Scientific reports · 2021Article
- Article
- Cloning, characterization, and functional analysis of acetyl-CoA C-acetyltransferase and 3-hydroxy-3-methylglutaryl-CoA synthase genes in Santalum album.Scientific reports · 2021Article
- Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action.Molecules (Basel, Switzerland) · 2019Review
- Transcriptome and Metabolite Profiling Reveal Novel Insights into Volatile Heterosis in the Tea Plant (Molecules (Basel, Switzerland) · 2019Article
- Directed evolution of mevalonate kinase inRSC advances · 2018Article
- Volatile terpenoids: multiple functions, biosynthesis, modulation and manipulation by genetic engineering.Planta · 2017Review
- Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications.3 Biotech · 2015Article
- Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza.Journal of experimental botany · 2012Article
- Terpene Specialized Metabolism in Arabidopsis thaliana.The arabidopsis book · 2011Article
- Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston].BMC molecular biology · 2010Article
- Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes.Genome biology · 2009Article
- Arabidopsis thaliana contains a single gene encoding squalene synthase.Plant molecular biology · 2008Article
- Article
- Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway.Plant physiology · 2002Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mevalonate kinase (MVK), the enzyme that catalyzes the phosphorylation of mevalonate to produce mevalonate 5-phosphate, is considered as a potential regulatory enzyme of the isoprenoid biosynthetic pathway. The Arabidopsis thaliana MVK gene corresponding to the MVK cDNA previously isolated has been cloned and characterized. RNAse protection analysis indicated that the expression of the MVK gene generates three mRNA populations with 5' ends mapping 203, 254 and 355 nt upstream of the MVK ATG start codon. Northern blot analysis showed that the MVK mRNA accumulates preferentially in roots and influorescences. Histochemical analysis, with transgenic A. thaliana plants containing a translational fusion of a 1.8 kb fragment of the 5' region of the MVK gene to the beta-glucuronidase (GUS) reporter gene, indicated that the MVK 5'-flanking region directs widespread expression of the GUS gene throughout development, although the highest levels of GUS activity are detected in roots (meristematic region) and flowers (sepals, petals, anthers, style and stigmatic papillae). The expression pattern of the MVK gene suggests that the role of the encoded MVK is the production of a general pool of mevalonate-5-phosphate for the synthesis of different classes of isoprenoids involved in both basic and specialized plant cell functions. Functional promoter deletion analysis in transfected A. thaliana protoplasts indicated that regulatory elements between positions -295 and -194 of the MVK 5'-flanking region are crucial for high-level MVK gene expression.
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