ArticleThe American journal of pathology2000
Degranulating eosinophils in human endometriosis.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Targeting the Immune Network in Endometriosis: A Comprehensive Review of Pathogenesis, Immunomodulation, and Emerging Therapies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Activated eosinophil plays a role in promoting fibrosis in endometriotic lesion.Scientific reports · 2025Article
- Immunopathological insights into endometriosis: from research advances to future treatments.Seminars in immunopathology · 2025Review
- Exploring the Immunological Aspects and Treatments of Recurrent Pregnancy Loss and Recurrent Implantation Failure.International journal of molecular sciences · 2025Review
- The Estrogen-Immune Interface in Endometriosis.Cells · 2025Review
- Association of endometriosis with asthma: a study of the NHANES database in 1999-2006.Journal of health, population, and nutrition · 2024Article
- The endometrial immune environment of women with endometriosis.Human reproduction update · 2019Review
- IL-4-secreting eosinophils promote endometrial stromal cell proliferation and preventProceedings of the National Academy of Sciences of the United States of America · 2017Article
- The usefulness of uterine lavage and acute phase protein levels as a diagnostic tool for subclinical endometritis in Icelandic mares.Acta veterinaria Scandinavica · 2016Article
- Review
- Endometriosis, need for a multidisciplinary clinical setting: the internist's point of view.Internal and emergency medicine · 2010Review
- Eosinophils in health and disease: the LIAR hypothesis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2010Article
- Current concepts of the pathogenesis of endometriosis.Reproductive medicine and biology · 2010Review
- Interleukin-4 stimulates proliferation of endometriotic stromal cells.The American journal of pathology · 2008Article
- Danger signals derived from stressed and necrotic epithelial cells activate human eosinophils.Immunology · 2004Article
- Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophilia.Infection and immunity · 2003Article
- Adenomyosis--a result of disordered stromal differentiation.The American journal of pathology · 2001Article
- Regulated on activation, normal T-cell-expressed and -secreted mRNA expression in normal endometrium and endometriotic implants: assessment of autocrine/paracrine regulation by in situ hybridization.The American journal of pathology · 2001Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Degranulating eosinophils have been described in most endometrial cancers. We hypothesized that endometriosis (ectopic, nonneoplastic endometrial tissue) would be an appropriate model system for determining whether eosinophil degranulation is part of a specific immune response to endometrial cancer or if it is related to the more general phenomenon of tissue remodeling (wound healing) that is common to both disorders. To test this hypothesis, we performed immunohistochemistry and Western blotting to evaluate the presence of eosinophil peroxidase (a marker of eosinophil degranulation) in normal endometrium (n = 20) and endometriosis samples (n = 24) and to define the coexpression of three eosinophil chemoattractants: interleukin-5 (IL-5), eotaxin, and regulated on activator-normal T cell expressed and secreted (RANTES). There was focally intense deposition of eosinophil peroxidase in the fibrotic connective tissue and blood vessels of 21 of 24 human endometriosis specimens; two samples showed weak staining, and only one tissue was negative for eosinophil degranulation. None of the 10 normal proliferative endometrial specimens had evidence of eosinophil degranulation, and four of 10 secretory tissues stained only weakly for eosinophil peroxidase. The presence of degranulating eosinophils was also associated with the presence of eotaxin and IL-5 in some samples and with RANTES in others. We conclude that the abundant presence of degranulating eosinophils in the fibrous regions of endometriosis supports the interpretation that eosinophils are involved in general tissue remodeling and wound healing rather than a tissue-directed immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.