ArticleClinical and experimental immunology2000
Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw.
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 73 citations in OpenAlex.
- IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Ketamine attenuates osteoarthritis of the knee via modulation of inflammatory responses in a rabbit model.Molecular medicine reports · 2016Article
- The therapeutic potential of interleukin-10 in neuroimmune diseases.Neuropharmacology · 2015Review
- Activation of Nicotinic Receptors Inhibits TNF-α-Induced Production of Pro-inflammatory Mediators Through the JAK2/STAT3 Signaling Pathway in Fibroblast-Like Synoviocytes.Inflammation · 2015Article
- Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis.Arthritis research & therapy · 2014Article
- The enigmatic cytokine oncostatin m and roles in disease.ISRN inflammation · 2013Review
- TLR2 deletion promotes arthritis through reduction of IL-10.Journal of leukocyte biology · 2013Article
- Interleukin-22 reduces the severity of collagen-induced arthritis in association with increased levels of interleukin-10.Arthritis and rheumatism · 2013Article
- Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation.Pathobiology of aging & age related diseases · 2012Article
- Regulatory T cell-mediated control of autoantibody-induced inflammation.Frontiers in immunology · 2012Article
- Mechanotransduction and cartilage integrity.Annals of the New York Academy of Sciences · 2011Review
- Non-invasive screening of progressive joint defects in the Type II collagen-induced arthritis animal model using radiographic paw images.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Evaluation of inflammatory change and bone erosion using a murine type II collagen-induced arthritis model.Rheumatology international · 2011Article
- Structure and function of interleukin-22 and other members of the interleukin-10 family.Cellular and molecular life sciences : CMLS · 2010Review
- The vagus nerve and nicotinic receptors involve inhibition of HMGB1 release and early pro-inflammatory cytokines function in collagen-induced arthritis.Journal of clinical immunology · 2010Article
- A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis.Arthritis research & therapy · 2010Article
- Scorpion venom and the inflammatory response.Mediators of inflammation · 2010Review
- Concepts in gene therapy for cartilage repair.Injury · 2008Review
- Role of leukotriene B4 receptors in rheumatoid arthritis.Autoimmunity reviews · 2007Review
- Biomechanical signals suppress proinflammatory responses in cartilage: early events in experimental antigen-induced arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the effects of local IL-10 application, introduced by a recombinant human type 5 adenovirus vector, in the mouse knee joint during the early phase of CIA. One intra-articular injection with the IL-10-expressing virus (Ad5E1mIL-10) caused substantial over-expression of IL-10 in the mouse knee joint, using virus dosages which did not induce distracting inflammation. High expression of IL-10 was noted for a few days, being maximal at day 1. One intra-articular injection of Ad5E1mIL-10 in the knee joints of collagen type II (CII)-immunized mice, before onset of CIA was noted, reduced the incidence of collagen arthritis in that knee. Of high interest, the protective effect of local IL-10 expression by Ad5E1mIL-10 was not restricted to the knee joint alone. The arthritis incidence in the ipsilateral paw was highly suppressed. In contrast, local IL-10 over-expression was not effective when treatment was started after onset of CIA. Further analysis in the acute streptococcal cell wall-induced arthritis model revealed that local IL-10 over-expression markedly suppressed the production of tumour necrosis factor-alpha (TNF-alpha) and IL-1alpha, but had no significant effect on IL-1beta and IL-12 production in the inflamed synovium. These data indicate that local over-expression of IL-10 in the knee joint of mice regulates the expression of collagen arthritis, probably through down-regulation of TNF-alpha.
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