ArticleClinical and experimental immunology2000
The proportion of circulating gammadelta T cells increases after the first week of onset of tularaemia and remains elevated for more than a year.
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Immunological changes associated with the treatment of pneumonic tularaemia in marmosets.Frontiers in cellular and infection microbiology · 2026Article
- The immune response toFrontiers in microbiology · 2025Review
- Marmosets as models of infectious diseases.Frontiers in cellular and infection microbiology · 2024Review
- A diversified role for γδT cells in vector-borne diseases.Frontiers in immunology · 2022Review
- Structure-Activity Relationships of Butyrophilin 3 Ligands.ChemMedChem · 2020Review
- Review
- Early Diagnosis of Tularemia by Flow Cytometry, Czech Republic, 2003-2015Emerging infectious diseases · 2019Article
- Gamma delta T cell expansion in Whipple's disease with muscular granulomatous vasculitis.Infection · 2018Article
- Adaptive Immunity toFrontiers in cellular and infection microbiology · 2018Review
- Quantitative peripheral blood perturbations of γδ T cells in human disease and their clinical implications.Clinical reviews in allergy & immunology · 2014Review
- Ex vivo restimulation of human PBMC expands a CD3+CD4-CD8- γδ+ T cell population that can confound the evaluation of CD4 and CD8 T cell responses to vaccination.Clinical & developmental immunology · 2013Article
- Regulation and function of IL-17A- and IL-22-producing γδ T cells.Cellular and molecular life sciences : CMLS · 2011Review
- Immunity to Francisella.Frontiers in microbiology · 2011Article
- Characterization of lethal inhalational infection with Francisella tularensis in the common marmoset (Callithrix jacchus).Journal of medical microbiology · 2010Article
- The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.PloS one · 2010Article
- Oropharyngeal tularemia--a differential diagnosis of tonsillopharyngitis and cervical lymphadenitis.Wiener klinische Wochenschrift · 2010Article
- Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development.Microbiology and molecular biology reviews : MMBR · 2009Review
- Article
- Transcriptional profiling of the peripheral blood response during tularemia.Genes and immunity · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In various human intracellular bacterial diseases, an increase of the proportion of circulating Vgamma9Vdelta2 T cells has been observed. The prevalence of the finding among infected subjects and the time course of the elevation remain to be investigated. In the present study, comprising blood samples from a large number of cases of ulceroglandular tularaemia, the percentage of Vgamma9Vdelta2 T cells within the first week of onset of disease (5.3 +/- 0.7% (mean +/- s.e.m.)) did not differ from that of control subjects (5.3 +/- 0. 8%). Thereafter, percentages increased rapidly and within the interval of 8-40 days mean levels were > 20% (P < 0.001). Of 45 individuals sampled within 3 months of onset, 42 showed a percentage of Vgamma9Vdelta2 T cells of > 10%. Significantly increased levels were still recorded at 18 months (13.8 +/- 2.4%; P < 0.05) but not at 24 months (10.2 +/- 2.1%; P > 0.10). Thus, a consistent increase of circulating Vgamma9Vdelta2 T cells was demonstrated in tularaemia. The initial delay and the prolonged course of elevation may suggest a role in immunoregulation and/or immunological memory. Furthermore, the percentage of gammadelta T cells expressing tumour necrosis factor-alpha in response to phorbol myristate acetate was decreased during the first week and up to 40 days after onset, possibly reflecting the modulation of an inflammatory response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.