ArticleClinical and experimental immunology2000
The 19-kD antigen and protective immunity in a murine model of tuberculosis.
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
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- Scrutiny of Mycobacterium tuberculosis 19 kDa antigen proteoforms provides new insights in the lipoglycoprotein biogenesis paradigm.Scientific reports · 2017Article
- Impact of toll-like receptor 2 deficiency on immune responses to mycobacterial antigens.Infection and immunity · 2011Article
- A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis.Nature medicine · 2011Article
- Relief from Zmp1-mediated arrest of phagosome maturation is associated with facilitated presentation and enhanced immunogenicity of mycobacterial antigens.Clinical and vaccine immunology : CVI · 2011Article
- Modulation of cell death by M. tuberculosis as a strategy for pathogen survival.Clinical & developmental immunology · 2011Article
- Suppression of allergic airway inflammation in a mouse model by Der p2 recombined BCG.Immunology · 2009Article
- Enhanced protection against bovine tuberculosis after coadministration of Mycobacterium bovis BCG with a Mycobacterial protein vaccine-adjuvant combination but not after coadministration of adjuvant alone.Clinical and vaccine immunology : CVI · 2008Article
- Vaccines for tuberculosis: novel concepts and recent progress.Clinical microbiology reviews · 2005Review
- Pulmonary DNA vaccination: concepts, possibilities and perspectives.Journal of controlled release : official journal of the Controlled Release Society · 2005Review
- A limited antigen-specific cellular response is sufficient for the early control of Mycobacterium tuberculosis in the lung but is insufficient for long-term survival.Infection and immunity · 2004Article
- The Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits gamma interferon-regulated HLA-DR and Fc gamma R1 on human macrophages through Toll-like receptor 2.Infection and immunity · 2003Article
- Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence.Clinical microbiology reviews · 2003Review
- The Mycobacterium tuberculosis recombinant 27-kilodalton lipoprotein induces a strong Th1-type immune response deleterious to protection.Infection and immunity · 2003Article
- On the use of DNA vaccines for the prophylaxis of mycobacterial diseases.Infection and immunity · 2003Review
- Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The 19-kD antigen is a cell wall-associated lipoprotein present in Mycobacterium tuberculosis and in bacille Calmette-Guérin (BCG) vaccine strains. Expression of the 19-kD antigen as a recombinant protein in two saprophytic mycobacteria-M. vaccae and M. smegmatis-resulted in abrogation of their ability to confer protection against M. tuberculosis in a murine challenge model, and in their ability to prime a DTH response to cross-reactive mycobacterial antigens. Induction of an immune response to the 19-kD antigen by an alternative approach of DNA vaccination had no effect on subsequent M. tuberculosis challenge. These results are consistent with a model in which the presence of the 19-kD protein has a detrimental effect on the efficacy of vaccination with live mycobacteria. Targeted inactivation of genes encoding selected antigens represents a potential route towards development of improved vaccine candidates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.