ArticleClinical and experimental immunology2000
Cytolytic mechanisms of intraepithelial lymphocytes in coeliac disease (CoD).
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Cerebellar presence of immune cells in patients with neuro-coeliac disease.Acta neuropathologica communications · 2023Article
- Colitis nucleomigrans: The third type of microscopic colitis (part 2). An ultrastructural study.Pathology international · 2020Article
- Colitis nucleomigrans: The third type of microscopic colitis (part 1).Pathology international · 2020Article
- Evolving Therapy for Celiac Disease.Frontiers in pediatrics · 2019Review
- The elusive case of human intraepithelial T cells in gut homeostasis and inflammation.Nature reviews. Gastroenterology & hepatology · 2018Review
- Common ground: shared risk factors for type 1 diabetes and celiac disease.Nature immunology · 2018Review
- Celiac disease: understanding the gluten-free diet.European journal of nutrition · 2017Review
- Mesenchymal stem cells as potential therapeutic approaches in celiac disease.Gastroenterology and hepatology from bed to bench · 2016Review
- Are stem cells a potential therapeutic tool in coeliac disease?Cellular and molecular life sciences : CMLS · 2015Review
- Immune responses to HIV and SIV in mucosal tissues: 'location, location, location'.Current opinion in HIV and AIDS · 2010Review
- Gliadin activates HLA class I-restricted CD8+ T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis.Gastroenterology · 2008Article
- Article
- Article
- Interleukin-12 up-regulates perforin- and Fas-mediated lymphokine-activated killer activity by intestinal intraepithelial lymphocytes.Clinical and experimental immunology · 2004Article
- Immunohistochemical study of the apoptotic mechanisms in the intestinal mucosa during children's coeliac disease.Virchows Archiv : an international journal of pathology · 2003Article
- Article
- Mechanisms of villous atrophy in autoimmune enteropathy and coeliac disease.Clinical and experimental immunology · 2002Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effector arm of the mucosal immune system comprises lymphocytes scattered at intraepithelial and lamina propria levels. Intraepithelial lymphocytes (IEL) are a large population of oligoclonal resting cells which exhibit phenotypic and functional characteristics of cytolytic T cells when activated. Several mechanisms have been demonstrated to account for their cytotoxicity. Among them, one is mediated by perforin and granzyme molecules, another is mediated by Fas ligand (FasL) which delivers apoptotic signals through Fas receptor on target cells. There is good evidence that a flat intestinal mucosa may be produced by activated T cells. The aim of our study was to evaluate FasL and perforin expression by IEL, and its possible correlation with the increased enterocyte apoptosis in coeliac mucosa. Endoscopic duodenal biopsy specimens from 10 untreated coeliac patients, 10 treated coeliac patients, and 10 biopsied controls were evaluated for enterocyte apoptosis by terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine triphosphate nick end label method, for perforin expression by immunohistochemistry, and for FasL expression by immunocytochemistry. In untreated CoD there was a significant increase of percentage of both FasL+ and perforin+ IEL which positively correlated with enterocyte apoptosis in comparison with controls. All these parameters were significantly lower in treated CoD, even though they did not normalize. Our study demonstrates that in untreated CoD FasL and perforin expression by IEL is increased, and significantly correlates with the level of enterocyte apoptosis.
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