ArticleThe Journal of clinical investigation2000
Genes that modify the hemochromatosis phenotype in mice.
Article in The Journal of clinical investigation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 214 citations in OpenAlex.
- The neogenin-hemojuvelin axis in murine liver is crucial for hepcidin expression.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- FAM96A functions as a novel pace controller for iron uptake to maintain iron homeostasis and erythropoiesis.Cell death and differentiation · 2026Article
- Targeting ferroptosis to overcome drug resistance in lung cancer.Translational lung cancer research · 2025Review
- Revisiting hemochromatosis: geneticAnnals of translational medicine · 2021Review
- Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.Advances in biological regulation · 2020Article
- Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer.Asian journal of pharmaceutical sciences · 2020Article
- Article
- HFE Related Hemochromatosis: Uncovering the Inextricable Link between Iron Homeostasis and the Immunological System.Pharmaceuticals (Basel, Switzerland) · 2019Article
- Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2019Article
- Iron and Ferritin Modulate MHC Class I Expression and NK Cell Recognition.Frontiers in immunology · 2019Article
- Oral nucleic acid therapy using multicompartmental delivery systems.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018Review
- Iron overload exacerbates age-associated cardiac hypertrophy in a mouse model of hemochromatosis.Scientific reports · 2017Article
- Effect of the Hemochromatosis Mutations on Iron Overload among the Indian β Thalassemia Carriers.Journal of clinical laboratory analysis · 2017Article
- Pathophysiological consequences and benefits ofHaematologica · 2017Review
- Pulmonary Iron Homeostasis in Hepcidin Knockout Mice.Frontiers in physiology · 2017Article
- Mechanisms of divalent metal toxicity in affective disorders.Toxicology · 2016Review
- Effect of olfactory manganese exposure on anxiety-related behavior in a mouse model of iron overload hemochromatosis.Environmental toxicology and pharmacology · 2015Article
- The ins and outs of bacterial iron metabolism.Molecular microbiology · 2014Review
- Epistasis in iron metabolism: complex interactions between Cp, Mon1a, and Slc40a1 loci and tissue iron in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Hereditary hemochromatosis (HH) is a prevalent human disease caused by a mutation in HFE, which encodes an atypical HLA class I protein involved in regulation of intestinal iron absorption. To gain insight into the pathogenesis of hemochromatosis, we have bred Hfe knockout mice to strains carrying other mutations that impair normal iron metabolism. Compound mutant mice lacking both Hfe and its interacting protein, beta-2 microglobulin (B2m), deposit more tissue iron than mice lacking Hfe only, suggesting that another B2m-interacting protein may be involved in iron regulation. Hfe knockout mice carrying mutations in the iron transporter DMT1 fail to load iron, indicating that hemochromatosis involves iron flux through DMT1. Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well. Finally, compound mutants lacking Hfe and the transferrin receptor accumulate more tissue iron than do mice lacking Hfe alone, consistent with the idea that interaction between these two proteins contributes to the control of normal iron absorption. In addition to providing insight into the pathogenesis of HH, our results suggest that each of these genes might be a candidate modifier of the human hemochromatosis phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.