ReviewJournal of mammary gland biology and neoplasia2000
Local IGF-I axis in peripubertal ruminant mammary development.
Review in Journal of mammary gland biology and neoplasia, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 67 citations in OpenAlex.
- Making future udders: Mammary development and perinatal programming of dairy cattle.JDS communications · 2025Review
- Effects of two different rates of body weight gain during the first trimester of pregnancy or supplementing vitamins and minerals throughout pregnancy on primiparous beef cow milk production and composition.Translational animal science · 2025Article
- 14-3-3β is essential for milk composition stimulated by Leu/IGF-1 via IGF1R signaling pathway in BMECs.In vitro cellular & developmental biology. Animal · 2022Article
- Mulberry Leaf Flavonoids Improve Milk Production, Antioxidant, and Metabolic Status of Water Buffaloes.Frontiers in veterinary science · 2020Article
- Mammary Epithelial Cell Lineage Changes During Cow's Life.Journal of mammary gland biology and neoplasia · 2019Article
- Nutritional impact on mammary development in pigs: a review.Journal of animal science · 2018Review
- TRIENNIAL LACTATION SYMPOSIUM/BOLFA: Plasticity of mammary development in the prepubertal bovine mammary gland.Journal of animal science · 2017Review
- Up-regulation of integrin α6β4 expression by mitogens involved in dairy cow mammary development.In vitro cellular & developmental biology. Animal · 2015Article
- Transcriptome analysis of epithelial and stromal contributions to mammogenesis in three week prepartum cows.PloS one · 2011Article
- Article
- Establishing a framework for the functional mammary gland: from endocrinology to morphology.Journal of mammary gland biology and neoplasia · 2002Review
- IGF-I stimulation of extracellular acidification is not linked to cell proliferation for autocrine cells.Endocrine · 2001Article
- Real-time detection of insulin-like growth factor-1 stimulation of the MAC-T bovine mammary epithelial cell line.Endocrine · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulation of mammary growth and development in heifers is accomplished by complex interactions of hormones, growth factors, and extracellular matrix molecules. Many of these growth stimulators are believed to be locally produced in the mammary gland and to be affected by developmental and nutritional status. Although estrogen and growth hormone are considered critical to pubertal mammogenesis, results summarized in this review suggest that IGF-I and IGF binding proteins are especially important locally-produced growth regulators in peripubertal ruminants. This assertion is supported by studies of ovariectomized heifers, in which increased stromal IGFBP-3 and reduced IGF-I correspond with a failure of udder development. Similarly, reduced mammary development with overfeeding coincides with reduced mitogenic activity of mammary tissue extracts and altered concentrations of IGF-I and IGFBPs. In vitro studies convincingly demonstrate that much of the mitogenic activity of mammary extracts or serum can be attributed to IGF-I and that alterations in IGFBP-3 modulate its effectiveness. Thus by analogy to second messenger mechanisms of action for protein hormones, local mammary-derived growth factors likely explain many of the effects attributed to the classic mammogenic hormones.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.