ArticleThe Journal of experimental medicine2000
Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer's patches.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 140 citations in OpenAlex.
- GPR15-GPR15L axis controls colon natural TCRαβ cells residency and enteroendocrine cell homeostasis to calibrate metabolism.Mucosal immunology · 2026Article
- An SSTR2-somatostatin chemotactic axis drives T cell progenitor homing to the intestines.Nature immunology · 2025Article
- Decreased gene expression of interleukin 2 receptor subunit γ (CD132) in tissues of patients with Crohn's disease.World journal of gastroenterology · 2025Article
- Intraepithelial Lymphocytes of the Intestine.Annual review of immunology · 2024Review
- Epithelial regulation of microbiota-immune cell dynamics.Mucosal immunology · 2024Review
- The intestinal γδ T cells: functions in the gut and in the distant organs.Frontiers in immunology · 2023Review
- Dihydromyricetin Attenuates High-Intensity Exercise-Induced Intestinal Barrier Dysfunction Associated with the Modulation of the Phenotype of Intestinal Intraepithelial Lymphocytes.International journal of molecular sciences · 2022Article
- Three Layers of Intestinal γδ T Cells Talk Different Languages With the Microbiota.Frontiers in immunology · 2022Review
- Altered Gut Microbiome and Fecal Immune Phenotype in Early Preterm Infants With Leaky Gut.Frontiers in immunology · 2022Article
- T cell regeneration after immunological injury.Nature reviews. Immunology · 2021Review
- Murine CXCR3Frontiers in immunology · 2021Article
- γδ T cell migration: Separating trafficking from surveillance behaviors at barrier surfaces.Immunological reviews · 2020Review
- Review
- Anti-CTLA-4 synergizes with dendritic cell-targeted vaccine to promote IL-3-dependent CD4Annals of the New York Academy of Sciences · 2019Article
- Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease.JCI insight · 2018Article
- NAD(P)H Oxidase Activity in the Small Intestine Is Predominantly Found in Enterocytes, Not Professional Phagocytes.International journal of molecular sciences · 2018Article
- Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells.Frontiers in immunology · 2018Review
- Intestinal Barrier Interactions with Specialized CD8 T Cells.Frontiers in immunology · 2017Review
- The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine.PloS one · 2017Article
- The unique surface molecules on intestinal intraepithelial lymphocytes: from tethering to recognizing.Digestive diseases and sciences · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The intestinal mucosa is suggested to support extrathymic T cell development, particularly for T cell receptor (TCR)-gammadelta intraepithelial lymphocytes (IELs). TCR-gammadelta cell development requires interleukin (IL)-7; IL-7(-/)- or IL-7 receptor(-/)- mice lack TCR-gammadelta cells. Using the intestinal fatty acid binding protein (iFABP) promoter, we reinstated expression of IL-7 to mature enterocytes of IL-7(-/)- mice (iFABP-IL7). In iFABP-IL7 mice, TCR-gammadelta IELs were restored, as were cryptopatches and Peyer's patches. TCR-gammadelta cells remained absent from all other tissues. Likewise, T cell development in thymus and B cell maturation in the bone marrow and spleen retained the IL-7(-/)- phenotype. Thus, IL-7 expression by enterocytes was sufficient for extrathymic development of TCR-gammadelta cells in situ within the intestinal epithelium and was crucial for organization of mucosal lymphoid tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.