ArticleGenetics2000
Heritability of the maternal meiotic drive system linked to Om and high-resolution mapping of the Responder locus in mouse.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Ooplasmic transfer in human oocytes: efficacy and concerns in assisted reproduction.Reproductive biology and endocrinology : RB&E · 2017Review
- A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.PLoS genetics · 2015Article
- Article
- Article
- Effects of ooplasm transfer on paternal genome function in mice.Human reproduction (Oxford, England) · 2009Article
- The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome.Biology of reproduction · 2009Article
- Characterization of two Mst1-deficient mouse models.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- A search for transmission ratio distortions in offspring from crosses between inbred mice.Journal of genetics · 2008Article
- Nondisjunction and transmission ratio distortion ofChromosome 2 in a (2.8) Robertsonian translocation mouse strain.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11.Genetics · 2006Article
- On the evolutionary stability of Mendelian segregation.Genetics · 2005Article
- Maternal transmission ratio distortion at the mouse Om locus results from meiotic drive at the second meiotic division.Genetics · 2005Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Matings between (C57BL/6 x DDK)F(1) females and C57BL/6 males result in a significant excess of offspring inheriting maternal DDK alleles in the central region of mouse chromosome 11 due to meiotic drive at the second meiotic division. We have shown previously that the locus subject to selection is in the vicinity of D11Mit66, a marker closely linked to the Om locus that controls the preimplantation embryo-lethal phenotype known as the "DDK syndrome." We have also shown that observation of meiotic drive in this system depends upon the genotype of the sire. Here we show that females that are heterozygous at Om retain the meiotic drive phenotype and define a 0.32-cM candidate interval for the Responder locus in this drive system. In addition, analysis of the inheritance of alleles at Om among the offspring of F(1) intercrosses indicates that the effect of the sire is determined by the sperm genotype at Om or a locus linked to Om.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.