ArticleThe Journal of physiology2000
Serotonin suppresses subthreshold and suprathreshold oscillatory activity of rat inferior olivary neurones in vitro.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits.Journal of neuropathology and experimental neurology · 2023Article
- Neural Burst Firing and Its Roles in Mental and Neurological Disorders.Frontiers in cellular neuroscience · 2021Article
- RNA interference of GluN1 inhibits neuronal rhythmogenesis in the adult inferior olive.Journal of molecular neuroscience : MN · 2015Article
- In and out of the loop: external and internal modulation of the olivo-cerebellar loop.Frontiers in neural circuits · 2013Review
- Consensus paper: pathological role of the cerebellum in autism.Cerebellum (London, England) · 2012Review
- Spontaneous cluster activity in the inferior olivary nucleus in brainstem slices from postnatal mice.The Journal of physiology · 2012Article
- Climbing fiber burst size and olivary sub-threshold oscillations in a network setting.PLoS computational biology · 2012Article
- Harmaline tremor: underlying mechanisms in a potential animal model of essential tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2012Article
- Bidirectional plasticity in the primate inferior olive induced by chronic ethanol intoxication and sustained abstinence.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A transcriptomic analysis of type I-III neurons in the bed nucleus of the stria terminalis.Molecular and cellular neurosciences · 2011Article
- Spontaneous rhythmogenic capabilities of sympathetic neuronal assemblies in the rat spinal cord slice.Neuroscience · 2010Article
- Differences in subthreshold resonance of hippocampal pyramidal cells and interneurons: the role of h-current and passive membrane characteristics.The Journal of physiology · 2010Article
- Serotonin evokes endocannabinoid release and retrogradely suppresses excitatory synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- In vivo mouse inferior olive neurons exhibit heterogeneous subthreshold oscillations and spiking patterns.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Rhythmic episodes of subthreshold membrane potential oscillations in the rat inferior olive nuclei in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Fundamental role of inferior olive connexin 36 in muscle coherence during tremor.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Two distinct oscillatory states determined by the NMDA receptor in rat inferior olive.The Journal of physiology · 2001Article
- The great gate: control of sensory information flow to the cerebellum.Cerebellum (London, England)Review
- The cerebellum and respiratory control.Cerebellum (London, England)Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The effect of serotonin on membrane potential oscillations of inferior olivary neurones was studied in brainstem slices from 10- to 19-day-old rats. Serotonin at 50 and 5 microM induced a mean depolarization of 9.4 and 7.7 mV, respectively, that was preceded by a reversible suppression of subthreshold membrane potential oscillations. These effects were not changed by 1 microM tetrodotoxin and the suppression of subthreshold oscillations persisted after current-mediated restoration of resting potential. In spontaneously active neurones, serotonin abolished the rhythmicity of action potential firing without affecting spike frequency. Serotonin reduced the slope of the calcium-mediated rebound spike and both the duration and amplitude of the subsequent afterhyperpolarization. Serotonin also shifted the voltage dependence of the rebound spike to more negative values. Hyperpolarizing current pulses (200 ms) revealed that serotonin increased the pre-rectification and steady-state components of membrane resistance by 37 and 38 %, respectively, in 66 % of neurones, but decreased these parameters by 14 and 20% in the remaining cells. The serotonin effects were antagonized by 5 microM methysergide or 1-5 microM ketanserin and were mimicked by 10-20 microM dimethoxy-4-iodoamphetamine but not 10 microM 8-hydroxy-2-(di-N-propylamino)-tetralin. The data indicate that serotonin suppresses the rhythmic activity of olivary neurones via 5-HT2 receptors by inhibition of the T-type calcium current in combination with membrane depolarization due to activation of a cation current (Ih) and block of a resting K+ current (fast IK(ir)). This modulatory action of serotonin may account for the differential propensity of olivary neurones to fire rhythmically during different behavioural states in vivo.
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