ArticleJournal of clinical microbiology2000
Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Article
- FimA genotype variants of Porphyromonas gingivalis in periodontal health and disease: a preliminary observational study among the UAE population.BMC oral health · 2025Observational
- Internalization and Colocalization of a Polyclonal Antibody Against Porphyromonas gingivalis FimA type I in Infected Cells.European journal of dentistry · 2025Article
- Linking Periodontitis with Inflammatory Bowel Disease through the Oral-Gut Axis: The Potential Role ofBiomedicines · 2024Review
- Article
- A Tale of Two Fimbriae: How Invasion of Dendritic Cells byPathogens (Basel, Switzerland) · 2022Review
- Distribution ofBiomedicines · 2020Article
- Structure of polymerized type V pilin reveals assembly mechanism involving protease-mediated strand exchange.Nature microbiology · 2020Article
- Variation in the Occurrence ofInternational journal of environmental research and public health · 2020Article
- Variability in Genomic and Virulent Properties ofFrontiers in cellular and infection microbiology · 2019Article
- Dominant prevalence ofJournal of dental sciences · 2017Article
- Article
- Prevalence of fimA genotypes of Porphyromonas gingivalis in adolescent orthodontic patients.PloS one · 2017Article
- Detection of Porphyromonas gingivalis fimA Type I Genotype in Gingivitis by Real-Time PCR-A Pilot Study.Journal of clinical and diagnostic research : JCDR · 2016Article
- Potent In Vitro and In Vivo Activity of Plantibody Specific for Porphyromonas gingivalis FimA.Clinical and vaccine immunology : CVI · 2016Article
- Prevalence of Porphyromonas gingivalis fimA genotypes in the peri-implant sulcus of Koreans assessed using a new primer.Journal of periodontal & implant science · 2016Article
- Porphyromonas gingivalis Fim-A genotype distribution among Colombians.Colombia medica (Cali, Colombia) · 2015Article
- Bacteria and bacterial DNA in atherosclerotic plaque and aneurysmal wall biopsies from patients with and without periodontitis.Journal of oral microbiology · 2014Article
- Article
- Variability of the fimA gene in Porphyromonas gingivalis isolated from periodontitis and non-periodontitis patients.Medicina oral, patologia oral y cirugia bucal · 2013Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Fimbriae of Porphyromonas gingivalis are filamentous appendages on the cell surface and are thought to be one of the virulence factors. The fimA gene encoding the subunit protein of fimbriae, fimbrillin (FimA), was classified into four typeable variants (types I to IV). We previously examined the distribution of P. gingivalis in terms of fimA genotypes in periodontitis patients using a fimA type-specific PCR assay. However, some patients harbored P. gingivalis with untypeable fimA. In this study, we have cloned a new type (type V) of fimA from dental plaque samples. P. gingivalis with type V fimA was isolated from dental plaque of a periodontitis patient, and the isolate was named HNA-99. The deduced amino acid sequences were compared with those of type I P. gingivalis ATCC 33277, type II strain HW24D1, type III strain 6/26, and type IV strain HG564, and the homologies were found to be 45, 44, 43, and 55%, respectively. Southern blot analysis showed that the clinical isolate HNA-99 possessed P. gingivalis-specific genes sod and kgp. However, in terms of serological specificities, type V FimA showed a difference from other types of FimA. In addition, type V P. gingivalis bacteria were detected in 16.4% (12 of 73) of the P. gingivalis-positive patients with periodontitis by PCR assay using specific primers. Thus, a new type of fimA gene is now established, and the fimA genotyping could be useful in determining the disease-associated genotypes of P. gingivalis involved in the development of adult periodontitis.
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