ArticleJournal of clinical microbiology2000
Distribution of genes encoding putative transmissibility factors among epidemic and nonepidemic strains of Burkholderia cepacia from cystic fibrosis patients in the United Kingdom.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Genomic Basis of Lifestyle Divergence in Rice-AssociatedInternational journal of molecular sciences · 2026Article
- A study on the occurrence of Burkholderia cepacia complex in ultrasound gels used in different veterinary clinical settings in India.Veterinary research communications · 2023Article
- Environmental Burkholderia cenocepacia Strain Enhances Fitness by Serial Passages during Long-Term Chronic Airways Infection in Mice.International journal of molecular sciences · 2017Article
- Burkholderia cepacia complex in Serbian patients with cystic fibrosis: prevalence and molecular epidemiology.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Lung transplantation for cystic fibrosis: results, indications, complications, and controversies.Seminars in respiratory and critical care medicine · 2015Review
- Identification, molecular characterisation and antimicrobial susceptibility of genomovars of the Burkholderia cepacia complex in Spain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Identification of functions linking quorum sensing with biofilm formation in Burkholderia cenocepacia H111.MicrobiologyOpen · 2012Article
- Diversity analysis of Burkholderia cepacia complex in the water bodies of West Lake, Hangzhou, China.Journal of microbiology (Seoul, Korea) · 2011Article
- Host evasion by Burkholderia cenocepacia.Frontiers in cellular and infection microbiology · 2011Review
- Revised approach for identification of isolates within the Burkholderia cepacia complex and description of clinical isolates not assigned to any of the known genomovars.Journal of clinical microbiology · 2007Article
- Diazotrophic burkholderia species associated with field-grown maize and sugarcane.Applied and environmental microbiology · 2006Article
- Molecular epidemiology and antibiotic susceptibility of Burkholderia cepacia-complex isolates from an Italian cystic fibrosis centre.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2006Article
- Transmission of Burkholderia cepacia complex: evidence for new epidemic clones infecting cystic fibrosis patients in Italy.Journal of clinical microbiology · 2005Article
- Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium.Infection and immunity · 2005Article
- Species distribution and ribotype diversity of Burkholderia cepacia complex isolates from French patients with cystic fibrosis.Journal of clinical microbiology · 2004Article
- Correlation of wbiI genotype, serotype, and isolate source within species of the Burkholderia cepacia complex.Journal of clinical microbiology · 2004Article
- Responses of well-differentiated airway epithelial cell cultures from healthy donors and patients with cystic fibrosis to Burkholderia cenocepacia infection.Infection and immunity · 2004Article
- Epidemiology and clinical course of Burkholderia cepacia complex infections, particularly those caused by different Burkholderia cenocepacia strains, among patients attending an Italian Cystic Fibrosis Center.Journal of clinical microbiology · 2004Article
- Transcriptional and posttranscriptional control of cable pilus gene expression in Burkholderia cenocepacia.Journal of bacteriology · 2004Article
- Molecular analysis of Burkholderia cepacia complex isolates from a Portuguese cystic fibrosis center: a 7-year study.Journal of clinical microbiology · 2003Article
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Abstract
In the last 15 years, Burkholderia cepacia has emerged as a significant pathogen in cystic fibrosis (CF) patients, mainly due to the severity of infection observed in a subset of patients and the fear of transmission of the organism to noncolonized patients. Although patients who deteriorate rapidly cannot be predicted by microbiological characteristics, three genetic markers have been described for strains that spread between patients. These are the cblA gene, encoding giant cable pili; a hybrid of two insertion sequences, IS1356 and IS402; and a 1.4-kb open reading frame known as the B. cepacia epidemic strain marker (BCESM). The latter two are of unknown function. An epidemic strain lineage was previously identified among CF patients in the United Kingdom that apparently had spread from North America and that was characterized by a specific random amplified polymorphic DNA (RAPD) pattern. We searched for the described genetic markers using specific PCR assays with 117 patient isolates of B. cepacia from 40 United Kingdom hospitals. Isolates were grouped according to genomovar and epidemic strain lineage RAPD pattern with a 10-base primer, P272. A total of 41 isolates from patients in 12 hospitals were classified as the epidemic strain, and 40 of these were distributed in genomovars IIIa (11 isolates), IIIb (1 isolate), and IIIc (28 isolates). All isolates of the epidemic strain were positive for the cblA gene and BCESM, but two lacked the insertion sequence hybrid. None of the 76 sporadic isolates contained cblA or the insertion sequence hybrid, but 11 of them were positive for BCESM. Nonepidemic isolates were distributed among genomovars I or IV (9), II (49), IIIa (11), IIIb (3), and IIIc (4). There were three clusters of cross-infection (one involving two patients and two involving three patients) with isolates of genomovar II. We conclude that in the United Kingdom, a single clonal lineage has spread between and within some hospitals providing care for CF patients. The presence of the cblA gene is the most specific marker for the epidemic strain. We recommend that all isolates of B. cepacia from CF patients should be screened by PCR to influence segregation and infection control strategies.
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