ArticleBritish journal of cancer2000
Space-time clustering patterns in childhood leukaemia support a role for infection.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Space-time clustering of childhood cancers: a systematic review and pooled analysis.European journal of epidemiology · 2019Pooled it
- Space-time clustering of childhood high hyperdiploid B-cell precursor acute lymphoblastic leukemia: a nationwide Swedish study.European journal of epidemiology · 2026Article
- Congenital Hypothyroidism: Space-Time Clustering of Thyroid Dysgenesis Indicates a Role for Environmental Factors in Disease Etiology.Thyroid : official journal of the American Thyroid Association · 2021Article
- Temporal trend and spatial distribution of acute lymphoblastic leukemia in Iranian children during 2006-2014: a mixed ecological study.Epidemiology and health · 2020Article
- Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003⁻2012) of Epidemiological Surveillance.International journal of environmental research and public health · 2018Article
- Space-Time Clustering of Childhood Leukemia: Evidence of an Association with ETV6-RUNX1 (TEL-AML1) Fusion.PloS one · 2017Article
- Cross-space-time clustering of childhood cancer in Great Britain: evidence for a common aetiology.International journal of cancer · 2014Article
- Space-time clustering of non-hodgkin lymphoma using residential histories in a Danish case-control study.PloS one · 2013Article
- Space-time clustering of childhood central nervous system tumours in Yorkshire, UK.BMC cancer · 2012Article
- Seroprevalence of human herpes simplex, hepatitis B and epstein-barr viruses in children with acute lymphoblastic leukemia in southern iran.Pathology oncology research : POR · 2010Article
- Spatial clustering and space-time clusters of leukemia among children in Germany, 1987-2007.European journal of epidemiology · 2010Article
- Under-five mortality: spatial-temporal clusters in Ifakara HDSS in South-eastern Tanzania.Global health action · 2010Article
- Knox meets Cox: adapting epidemiological space-time statistics to demographic studies.Demography · 2010Article
- Spatial and space-time clustering of childhood acute leukaemia in France from 1990 to 2000: a nationwide study.British journal of cancer · 2006Article
- Space-time clustering analyses of testicular cancer amongst 15-24-year-olds in Northern England.European journal of epidemiology · 2006Article
- Human herpes virus 6 or Epstein-Barr virus were not detected in Guthrie cards from children who later developed leukaemia.British journal of cancer · 2004Article
- Childhood leukaemia incidence and the population mixing hypothesis in US SEER data.British journal of cancer · 2004Article
- Space-time clustering analyses of childhood acute lymphoblastic leukaemia by immunophenotype.British journal of cancer · 2002Article
- An infectious aetiology for childhood brain tumours? Evidence from space-time clustering and seasonality analyses.British journal of cancer · 2002Article
- Examination of temporal trends in the incidence of childhood leukaemias and lymphomas provides aetiological clues.Leukemia · 2001Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies of space-time clustering in childhood leukaemia have produced equivocal and inconsistent results. To address this issue we have used Manchester Children's Tumour Registry leukaemia data in space-time clustering analyses. Knox tests for space-time interactions between cases were applied with fixed thresholds of close in space, <5 km and close in time <1 year apart. Addresses at birth as well as diagnosis were utilized. Tests were repeated replacing geographical distance with distance to the Nth nearest neighbour. N was chosen such that the mean distance was 5 km. Data were also examined by a second order procedure based on K-functions. All methods showed highly significant evidence of space-time clustering based on place of birth and time of diagnosis, particularly for all leukaemias aged 0-14 and 0-4 years, and acute lymphoblastic leukaemia (ALL) 0-4 years. Some results based on location at diagnosis were significant but mainly gave larger P-values. The results are consistent with an infectious hypothesis. Furthermore, we found an excess of male cases over females involved in space-time pairs. We suggest this may be related to genetic differences in susceptibility to infection between males and females. These findings provide the basis for future studies to identify possible infectious agents.
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