Evidence map›Paper›PMID 10786841›Full record

ArticleRNA (New York, N.Y.)2000

Guilt by association: the arginine case revisited.

R D Knight, L F Landweber

Open access · greenAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 44 citations in OpenAlex.

  1. Possible Ancestral Functions of the Genetic and RNA Operational Precodes and the Origin of the Genetic System.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021
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  4. Revisiting the physico-chemical hypothesis of code origin: an analysis based on code-sequence coevolution in a finite population.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2013
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  15. A new classification scheme of the genetic code.Journal of molecular evolution · 2004
    Article
  16. Article
  17. No accident: genetic codes freeze in error-correcting patterns of the standard genetic code.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2002
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

R D KnightDepartment of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544-1003, USA.
L F Landweber
Princeton University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

If the genetic code arose in an RNA world, present codon assignments may reflect primordial RNA-amino acid affinities. Whether aptamers selected from random pools to bind free amino acids do so using the cognate codons at their binding sites has been controversial. Here we defend and extend our previous analysis of arginine binding sites, and propose a model for the maintenance of codon-amino acid interactions through the evolution of amino acids from ribozyme cofactors into the building blocks of proteins.

Indexed as

Evolution, MolecularModels, GeneticAnticodonArginineArtifactsBase CompositionBase SequenceBiasBinding SitesCodonCoenzymesGenetic CodeLigandsMolecular Sequence DataOligoribonucleotidesRNAAnticodonArginineCodonCoenzymesLigandsOligoribonucleotidesRNARNA, Catalytic

Identifiers

PMID10786841
PMCPMC1369931
OpenAlexW2127303964

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.