ArticleRNA (New York, N.Y.)2000
The scene of a frozen accident.
Article in RNA (New York, N.Y.), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Recent Advances in Aptamer-Based Biosensors for Bacterial Detection.Biosensors · 2024Review
- Screening for Primordial RNA-Peptide Interactions Using High-Density Peptide Arrays.Life (Basel, Switzerland) · 2023Article
- Possible Ancestral Functions of the Genetic and RNA Operational Precodes and the Origin of the Genetic System.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021Article
- Inside the Black Box: What Makes SELEX Better?Molecules (Basel, Switzerland) · 2019Review
- In Vitro Selection and Characterization of a Single-Stranded DNA Aptamer Against the Herbicide Atrazine.ACS omega · 2018Article
- In Vitro Selection of a Single-Stranded DNA Molecular Recognition Element against the Pesticide Fipronil and Sensitive Detection in River Water.International journal of molecular sciences · 2017Article
- In Vitro Selection of a Single-Stranded DNA Molecular Recognition Element against Clostridium difficile Toxin B and Sensitive Detection in Human Fecal Matter.Journal of nucleic acids · 2015Article
- The scenario on the origin of translation in the RNA world: in principle of replication parsimony.Biology direct · 2010Article
- The transition from noncoded to coded protein synthesis: did coding mRNAs arise from stability-enhancing binding partners to tRNA?Biology direct · 2010Article
- RNA-amino acid binding: a stereochemical era for the genetic code.Journal of molecular evolution · 2009Review
- Origin and evolution of the genetic code: the universal enigma.IUBMB life · 2009Review
- Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code.Biology direct · 2008Article
- Bioinformatic analysis of the contribution of primer sequences to aptamer structures.Journal of molecular evolution · 2008Article
- The origin of modern terrestrial life.HFSP journal · 2007Article
- On the origin of the translation system and the genetic code in the RNA world by means of natural selection, exaptation, and subfunctionalization.Biology direct · 2007Article
- Evolutionary landscapes for the acquisition of new ligand recognition by RNA aptamers.Journal of molecular evolution · 2003Article
- Finding specific RNA motifs: function in a zeptomole world?RNA (New York, N.Y.) · 2003Article
- A minihelix-loop RNA acts as a trans-aminoacylation catalyst.RNA (New York, N.Y.) · 2001Article
- An in vitro evolved precursor tRNA with aminoacylation activity.The EMBO journal · 2001Article
- Guilt by association: the arginine case revisited.RNA (New York, N.Y.) · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been suggested that in vitro selection experiments can provide information not only on what might have occurred during the evolution of the RNA world, but can in fact yield insights into particular features of the RNA world. In particular, it has been suggested that the sequences of anti-amino acid aptamers can provide clues to the origin of the genetic code, and that there is a statistically significant association between motifs found in aptamers and codons. We argue that the suggested connections between modern motifs and ancient sequences are logically tenuous, and show that there is no statistically meaningful association between motifs found in aptamers and codons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.