ArticleCell2000
Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome.
Article in Cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 281 citations in OpenAlex.
- In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi).International journal of molecular sciences · 2020Article
- Association of potentially functional variants in the XPG gene with neuroblastoma risk in a Chinese population.Journal of cellular and molecular medicine · 2016Article
- Association between XPG polymorphisms and stomach cancer susceptibility in a Chinese population.Journal of cellular and molecular medicine · 2016Article
- Financial costs and personal consequences of research misconduct resulting in retracted publications.eLife · 2014Article
- Association of single nucleotide polymorphisms of nucleotide excision repair genes with laryngeal cancer risk and interaction with cigarette smoking and alcohol drinking.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations.Human genetics · 2012Article
- Mfd is required for rapid recovery of transcription following UV-induced DNA damage but not oxidative DNA damage in Escherichia coli.Journal of bacteriology · 2012Article
- Premature aging and cancer in nucleotide excision repair-disorders.DNA repair · 2011Review
- Preferential repair of the transcribed DNA strand in plants.Frontiers in plant science · 2011Article
- UV-induced DNA damage promotes resistance to the biotrophic pathogen Hyaloperonospora parasitica in Arabidopsis.Plant physiology · 2008Article
- Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes.Current genetics · 2008Review
- Increased apoptosis, p53 up-regulation, and cerebellar neuronal degeneration in repair-deficient Cockayne syndrome mice.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing.Nucleic acids research · 2007Review
- Cockayne syndrome in adults: review with clinical and pathologic study of a new case.Journal of child neurology · 2006Review
- Nucleotide excision repair and cancer.Journal of molecular histology · 2006Review
- Late activation of stress kinases (SAPK/JNK) by genotoxins requires the DNA repair proteins DNA-PKcs and CSB.Molecular biology of the cell · 2006Article
- Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.Molecular and cellular biology · 2005Article
- Transcription-associated breaks in xeroderma pigmentosum group D cells from patients with combined features of xeroderma pigmentosum and Cockayne syndrome.Molecular and cellular biology · 2005Article
- Oxidized guanine lesions and hOgg1 activity in lung cancer.Oncogene · 2005Article
- Molecular and cellular dissection of mating-type switching steps in Schizosaccharomyces pombe.Molecular and cellular biology · 2005Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2005-11-18Falsification/Fabrication of Data · Falsification/Fabrication of Image · Falsification/Fabrication of Results · Investigation by Company/Institution · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · NIH misconduct finding for Steven Anthony Leadon, 6/9/2006;
- Commented on by
- Retracted
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Analysis of transcription-coupled repair (TCR) of oxidative lesions here reveals strand-specific removal of 8-oxo-guanine (8-oxoG) and thymine glycol both in normal human cells and xeroderma pigmentosum (XP) cells defective in nucleotide excision repair. In contrast, Cockayne syndrome (CS) cells including CS-B, XP-B/CS, XP-D/CS, and XP-G/CS not only lack TCR but cannot remove 8-oxoG in a transcribed sequence, despite its proficient repair when not transcribed. The XP-G/CS defect uniquely slows lesion removal in nontranscribed sequences. Defective TCR leads to a mutation frequency at 8-oxoG of 30%-40% compared to the normal 1%-4%. Surprisingly, unrepaired 8-oxoG blocks transcription by RNA polymerase II. These data imply that TCR is required for polymerase release to allow repair and that CS results from defects in TCR of oxidative lesions.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.