Evidence map›Paper›PMID 10781568›Full record

ArticleJournal of bacteriology2000

The ArcB sensor kinase of Escherichia coli: genetic exploration of the transmembrane region.

O Kwon, D Georgellis, A S Lynch, D Boyd, E C Lin

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. The ArcAB Two-Component System: Function in Metabolism, Redox Control, and Infection.Microbiology and molecular biology reviews : MMBR · 2022
    Review
  4. Identification of Z nucleotides as an ancient signal for two-component system activation in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  5. Protein dosage of theJournal of bacteriology · 2020
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Haemophilus influenzae and oxidative stress.Frontiers in cellular and infection microbiology · 2012
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

O KwonDepartment of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
D Georgellis
A S Lynch
D Boyd
E C Lin
Harvard University · US

Funding

GLOBAL REGULATION OF AEROBIC METABOLISM IN BACTERIAR01GM040993 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI LIN, EDMUND C · 1989 to 2002
$823k
NIGMS NIH HHS GM40993
6 · The paper itself

Abstract

The Arc two-component signal transduction system of Escherichia coli regulates the expression of numerous operons in response to respiratory growth conditions. Cellular redox state or proton motive force (Delta(H(+))) has been proposed to be the signal for the membrane-associated ArcB sensor kinase. This study provided evidence for a short ArcB periplasmic bridge that contains a His47. The dispensability of this amino acid, the only amino acid with a pK in the physiological range, renders the Delta(H(+)) model unlikely. Furthermore, results from substituting membrane segments of ArcB with counterparts of MalF indicate that the region does not play a stereospecific role in signal reception.

Indexed as

Escherichia coli ProteinsAlkaline PhosphataseBacterial ProteinsCell MembraneCyclin-Dependent KinasesEscherichia coliHistidineMembrane ProteinsProtein KinasesProton-Motive ForceRecombinant Fusion ProteinsAlkaline PhosphatasearcB protein, E coliBacterial ProteinsCyclin-Dependent KinasesEscherichia coli ProteinsHistidineMembrane ProteinsphoA protein, E coliProtein KinasesRecombinant Fusion Proteins

Identifiers

PMID10781568
PMCPMC102008
OpenAlexW2163913754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.