ArticleJournal of bacteriology2000
NhaA, an Na(+)/H(+) antiporter involved in environmental survival of Vibrio cholerae.
Article in Journal of bacteriology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
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- Antarctic ice-free terrestrial microbial functional redundancy in core ecological functions and microhabitat-specific microbial taxa and adaptive strategy.Environmental microbiome · 2025Article
- Subzero cell division, respiration, and genomic traits of cryophilicFrontiers in microbiology · 2025Article
- Salinity-driven niche differentiation within the aquatic Luna-1 subcluster.ISME communications · 2025Article
- Bacterial population-level trade-offs between drought tolerance and resource acquisition traits impact decomposition.The ISME journal · 2024Article
- Isolation and Genomics ofMicrobiology spectrum · 2023Article
- Genomic and phenotypic characterization of a red-pigmented strain ofFrontiers in microbiology · 2023Article
- Microbial river-to-sea continuum: gradients in benthic and planktonic diversity, osmoregulation and nutrient cycling.Microbiome · 2021Article
- Functional Characterization of MultipleInternational journal of molecular sciences · 2021Article
- Achromobacter aestuarii sp. nov., Isolated from an Estuary.Current microbiology · 2021Article
- Population genomics of Vibrionaceae isolated from an endangered oasis reveals local adaptation after an environmental perturbation.BMC genomics · 2020Article
- Comparative genomics analysis of Nitriliruptoria reveals the genomic differences and salt adaptation strategies.Extremophiles : life under extreme conditions · 2020Article
- Occurrence and significance of pathogenicity and fitness islands in environmental vibrios.AMB Express · 2018Article
- Mrp Antiporters Have Important Roles in Diverse Bacteria and Archaea.Frontiers in microbiology · 2017Review
- Global Screening ofFrontiers in microbiology · 2017Article
- Genome sequencing reveals mechanisms for heavy metal resistance and polycyclic aromatic hydrocarbon degradation in Delftia lacustris strain LZ-C.Ecotoxicology (London, England) · 2016Article
- NhaP1 is a K+(Na+)/H+ antiporter required for growth and internal pH homeostasis of Vibrio cholerae at low extracellular pH.Microbiology (Reading, England) · 2012Article
- Motility and chemotaxis in alkaliphilic Bacillus species.Future microbiology · 2009Review
- OscR, a new osmolarity-responsive regulator in Vibrio cholerae.Journal of bacteriology · 2009Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio cholerae, the agent of cholera, is a normal inhabitant of aquatic environments, in which it survives under a wide range of conditions of pH and salinity. In this work, we identified the nhaA gene in a wild-type epidemic strain of V. cholerae O1. nhaA encodes a protein of 382 amino acids that is very similar to the proteins NhaA of Vibrio parahaemolyticus, Vibrio alginolyticus ( approximately 87% identity), and Escherichia coli (56% identity). V. cholerae NhaA complements an E. coli nhaA mutant, enabling it to grow in 700 mM NaCl, pH 7.5, indicating functional homology to E. coli NhaA. However, unlike E. coli, the growth of a nhaA-inactivated mutant of V. cholerae was not restricted at various pH and NaCl concentrations, although it was inhibited in the presence of 120 mM LiCl at pH 8.5. Nevertheless, using a nhaA'-lacZ transcriptional fusion, we observed induction of nhaA transcription by Na(+), Li(+), and K(+). These results strongly suggest that NhaA is an Na(+)/H(+) antiporter contributing to the Na(+)/H(+) homeostasis of V. cholerae. nhaA-related sequences were detected in all strains of V. cholerae from the various serogroups. This gene is presumably involved in the survival and persistence of free-living bacteria in their natural habitat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.