ArticleProceedings of the National Academy of Sciences of the United States of America2000
Searching for the prototypic eye genetic network: Sine oculis is essential for eye regeneration in planarians.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 151 citations in OpenAlex.
- LIM-HD transcription factors control axial patterning and specify distinct neuronal and intestinal cell identities in planarians.Open biology · 2023Article
- Principles of regeneration revealed by the planarian eye.Current opinion in cell biology · 2021Review
- Six1 promotes skeletal muscle thyroid hormone response through regulation of the MCT10 transporter.Skeletal muscle · 2021Article
- Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression.Biomolecules · 2021Review
- miR-8b is involved in brain and eye regeneration of Dugesia japonica in head regeneration.Biology open · 2021Article
- Systemic paralogy and function of retinal determination network homologs in arachnids.BMC genomics · 2020Article
- Evolution and development of complex eyes: a celebration of diversity.Development (Cambridge, England) · 2020Review
- Article
- Coordination between binocular field and spontaneous self-motion specifies the efficiency of planarians' photo-response orientation behavior.Communications biology · 2018Article
- The planarianThe Journal of experimental biology · 2017Article
- Chlorophyll derivatives enhance invertebrate red-light and ultraviolet phototaxis.Scientific reports · 2017Article
- Go ahead, grow a head! A planarian's guide to anterior regeneration.Regeneration (Oxford, England) · 2016Review
- Forkhead containing transcription factor Albino controls tetrapyrrole-based body pigmentation in planarian.Cell discovery · 2016Article
- Article
- The EYA-SO/SIX complex in development and disease.Pediatric nephrology (Berlin, Germany) · 2013Review
- RNA interference by feeding in vitro-synthesized double-stranded RNA to planarians: methodology and dynamics.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear.Hearing research · 2013Review
- Transcriptome analysis of the planarian eye identifies ovo as a specific regulator of eye regeneration.Cell reports · 2012Article
- Morphological and molecular development of the eyes during embryogenesis of the freshwater planarian Schmidtea polychroa.Development genes and evolution · 2012Article
- Evaluation of endogenous reference genes for analysis of gene expression with real-time RT-PCR during planarian regeneration.Molecular biology reports · 2011Article
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified a sine oculis gene in the planarian Girardia tigrina (Platyhelminthes; Turbellaria; Tricladida). The planarian sine oculis gene (Gtso) encodes a protein with a sine oculis (Six) domain and a homeodomain that shares significant sequence similarity with so proteins assigned to the Six-2 gene family. Gtso is expressed as a single transcript in both regenerating and fully developed eyes. Whole-mount in situ hybridization studies show exclusive expression in photoreceptor cells. Loss of function of Gtso by RNA interference during planarian regeneration inhibits eye regeneration completely. Gtso is also essential for maintenance of the differentiated state of photoreceptor cells. These results, combined with the previously demonstrated expression of Pax-6 in planarian eyes, suggest that the same basic gene regulatory circuit required for eye development in Drosophila and mouse is used in the prototypic eye spots of platyhelminthes and, therefore, is truly conserved during evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.