ArticleProceedings of the National Academy of Sciences of the United States of America2000
Evolution of Antp-class genes and differential expression of Hydra Hox/paraHox genes in anterior patterning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Gene Loss may have Shaped the Cnidarian and Bilaterian Hox and ParaHox Complement.Genome biology and evolution · 2023Article
- A Reference Genome from the Symbiotic Hydrozoan,G3 (Bethesda, Md.) · 2020Article
- Epigenomic landscape of enhancer elements during Hydra head organizer formation.Epigenetics & chromatin · 2020Article
- Conserved Patterns in Developmental Processes and Phases, Rather than Genes, Unite the Highly Divergent Bilateria.Life (Basel, Switzerland) · 2020Article
- How Weird is The Worm? Evolution of the Developmental Gene Toolkit inJournal of developmental biology · 2019Review
- Article
- Cellular and Molecular Mechanisms of Hydra Regeneration.Results and problems in cell differentiation · 2019Review
- Hox and Wnt pattern the primary body axis of an anthozoan cnidarian before gastrulation.Nature communications · 2018Article
- Msx1 and Msx2 function together in the regulation of primordial germ cell migration in the mouse.Developmental biology · 2016Article
- Silencing expression of the NANOG gene and changes in migration and metastasis of urinary bladder cancer cells.Archives of medical science : AMS · 2016Article
- The role of NANOG transcriptional factor in the development of malignant phenotype of cancer cells.Cancer biology & therapy · 2016Review
- The TALE face of Hox proteins in animal evolution.Frontiers in genetics · 2015Article
- Article
- Coral comparative genomics reveal expanded Hox cluster in the cnidarian-bilaterian ancestor.Integrative and comparative biology · 2012Article
- Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development.Development (Cambridge, England) · 2012Article
- Annelid Distal-less/Dlx duplications reveal varied post-duplication fates.BMC evolutionary biology · 2011Article
- The origin of patterning systems in bilateria-insights from the Hox and ParaHox genes in Acoelomorpha.Genomics, proteomics & bioinformatics · 2011Review
- The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction.Developmental biology · 2011Article
- Conserved and novel gene expression between regeneration and asexual fission in Nematostella vectensis.Development genes and evolution · 2009Article
- Are Hox genes ancestrally involved in axial patterning? Evidence from the hydrozoan Clytia hemisphaerica (Cnidaria).PloS one · 2009Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The conservation of developmental functions exerted by Antp-class homeoproteins in protostomes and deuterostomes suggested that homologs with related functions are present in diploblastic animals. Our phylogenetic analyses showed that Antp-class homeodomains belong either to non-Hox or to Hox/paraHox families. Among the 13 non-Hox families, 9 have diploblastic homologs, Msx, Emx, Barx, Evx, Tlx, NK-2, and Prh/Hex, Not, and Dlx, reported here. Among the Hox/paraHox, poriferan sequences were not found, and the cnidarian sequences formed at least five distinct cnox families. Two are significantly related to the paraHox Gsx (cnox-2) and the mox (cnox-5) sequences, whereas three display some relatedness to the Hox paralog groups 1 (cnox-1), 9/10 (cnox-3) and the paraHox cdx (cnox-4). Intermediate Hox/paraHox genes (PG 3 to 8 and lox) did not have clear cnidarian counterparts. In Hydra, cnox-1, cnox-2, and cnox-3 were not found chromosomally linked within a 150-kb range and displayed specific expression patterns in the adult head. During regeneration, cnox-1 was expressed as an early gene whatever the polarity, whereas cnox-2 was up-regulated later during head but not foot regeneration. Finally, cnox-3 expression was reestablished in the adult head once it was fully formed. These results suggest that the Hydra genes related to anterior Hox/paraHox genes are involved at different stages of apical differentiation. However, the positional information defining the oral/aboral axis in Hydra cannot be correlated strictly to that characterizing the anterior-posterior axis in vertebrates or arthropods.
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