ArticleBritish journal of cancer2000
Expression of alpha(v)beta6 integrin in oral leukoplakia.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 85 citations in OpenAlex.
- The epidermal integrin-mediated secretome regulates the skin microenvironment during tumorigenesis and repair.Matrix biology : journal of the International Society for Matrix Biology · 2024Review
- Near-infrared imaging of head and neck squamous cell carcinoma using indocyanine green that targets theJournal of biomedical optics · 2024Article
- Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment.International journal of molecular sciences · 2022Review
- Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer.Frontiers in pharmacology · 2022Review
- Article
- Suppression of αvβ6 Integrin Expression by Polymicrobial Oral Biofilms in Gingival Epithelial Cells.Scientific reports · 2017Article
- Correlation of Vascularization and Inflammation with Severity of Oral Leukoplakia.Iranian journal of pathology · 2017Article
- Integrin-mediated regulation of epidermal wound functions.Cell and tissue research · 2016Review
- Integrin Regulation of Epidermal Functions in Wounds.Advances in wound care · 2014Review
- Molecular imaging of integrin αvβ6 expression in living subjects.American journal of nuclear medicine and molecular imaging · 2014Review
- Molecular changes in invasive front of oral cancer.Journal of oral and maxillofacial pathology : JOMFP · 2013Review
- From phage display to nanoparticle delivery: functionalizing liposomes with multivalent peptides improves targeting to a cancer biomarker.Bioconjugate chemistry · 2013Article
- A liposomal drug platform overrides peptide ligand targeting to a cancer biomarker, irrespective of ligand affinity or density.PloS one · 2013Article
- Clinical significance of integrin αvβ6 expression effects on gastric carcinoma invasiveness and progression via cancer-associated fibroblasts.Medical oncology (Northwood, London, England) · 2013Article
- Epithelial integrins with special reference to oral epithelia.Journal of dental research · 2011Review
- Synthesis and biological evaluation of a peptide-paclitaxel conjugate which targets the integrin αvβ₆.Bioorganic & medicinal chemistry · 2011Article
- Why integrin as a primary target for imaging and therapy.Theranostics · 2011Article
- Article
- Defining the role of integrin alphavbeta6 in cancer.Current drug targets · 2009Review
- Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development.Clinical & experimental metastasis · 2008Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of alpha(v)beta6 integrin was examined in oral leukoplakia, lichen planus and squamous cell carcinomas using immunohistochemistry. Controls included oral mucosal wounds, chronically inflamed and normal oral mucosa. Integrins beta1, beta3, beta4, beta5, fibronectin and tenascin were also studied. The integrin alpha(v)beta6 was highly expressed throughout the whole lesion of 90% of the squamous cell carcinomas but was not present in any of the normal specimens. alpha(v)beta6 integrin was also expressed in 41% of the leukoplakia specimens, and 85% of the lichen planus samples, but in none of the tissues with inflammatory hyperplasia or chronic inflammation. The expression of beta1 integrins was localized in the basal layer, and that of the beta4 at the cell surface facing the basement membrane of all specimens. The integrins beta3 and beta5 were absent from all normal and leukoplakia specimens. Fibronectin and tenascin were present in the connective tissue underneath the epithelium of all the sections, and their expression was similar in both alpha(v)beta6-positive and alpha(v)beta6-negative tissues. A group of 28 leukoplakia patients were followed 1-4 years after first diagnosis. In this group, initially alpha(v)beta6 integrin-positive leukoplakia specimens had high tendency for disease progression while alpha(v)beta6-negative specimens did not progress. These results suggest that the expression of alpha(v)beta6 integrin could be associated in the malignant transformation of oral leukoplakias.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.