ArticleProceedings of the National Academy of Sciences of the United States of America2000
The fourth chromosome of Drosophila melanogaster: interspersed euchromatic and heterochromatic domains.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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75 citing papers in PubMed.
- roX1 and roX2 lncRNAs promote heterochromatinization in intestinal stem cells and impair longevity.EMBO reports · 2026Article
- Position effect variegation (PEV) as an aging clock: visualization of age-dependent loss of heterochromatin and longevity associated with enhanced heterochromatin.Scientific reports · 2026Article
- Visualizing Chromosome Territories and Nuclear Architecture of Large Plant Genomes Using Alien Introgressions.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The Paramount Role ofInsects · 2021Review
- Active retrotransposons help maintain pericentromeric heterochromatin required for faithful cell division.Genome research · 2020Article
- Loci associated with variation in gene expression and growth in juvenile salmon are influenced by the presence of a growth hormone transgene.BMC genomics · 2020Article
- The impact of genetic background and cell lineage on the level and pattern of gene expression in position effect variegation.Epigenetics & chromatin · 2019Article
- Nuclear Disposition of Alien Chromosome Introgressions into Wheat and Rye Using 3D-FISH.International journal of molecular sciences · 2019Article
- Tissue stem cells: the new actors in the aneuploidy field.Cell cycle (Georgetown, Tex.) · 2019Article
- Molecular and genetic organization of bands and interbands in the dot chromosome of Drosophila melanogaster.Chromosoma · 2019Article
- Influence of a growth hormone transgene on the genetic architecture of growth-related traits: A comparative analysis between transgenic and wild-type coho salmon.Evolutionary applications · 2018Article
- Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila.Nature communications · 2018Article
- TheGenetics · 2018Article
- Article
- Review
- The Drosophila DAXX-Like Protein (DLP) Cooperates with ASF1 for H3.3 Deposition and Heterochromatin Formation.Molecular and cellular biology · 2017Article
- Genomic changes following the reversal of a Y chromosome to an autosome in Drosophila pseudoobscura.Evolution; international journal of organic evolution · 2017Article
- Sensitivity of Allelic Divergence to Genomic Position: Lessons from the Drosophila tan Gene.G3 (Bethesda, Md.) · 2016Article
- Predictive Models of Recombination Rate Variation across the Drosophila melanogaster Genome.Genome biology and evolution · 2016Article
- Targeting of P-Element Reporters to Heterochromatic Domains by Transposable Element 1360 in Drosophila melanogaster.Genetics · 2016Article
15 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
The small fourth chromosome of Drosophila melanogaster (3.5% of the genome) presents a puzzle. Cytological analysis suggests that the bulk of the fourth, including the portion that appears banded in the polytene chromosomes, is heterochromatic; the banded region includes blocks of middle repetitious DNA associated with heterochromatin protein 1 (HP1). However, genetic screens indicate 50-75 genes in this region, a density similar to that in other euchromatic portions of the genome. Using a P element containing an hsp70-white gene and a copy of hsp26 (marked with a fragment of plant DNA designated pt), we have identified domains that allow for full expression of the white marker (R domains), and others that induce a variegating phenotype (V domains). In the former case, the hsp26-pt gene shows an accessibility and heat-shock-inducible activity similar to that seen in euchromatin, whereas in the latter case, accessibility and inducible expression are reduced to levels typical of heterochromatin. Mapping by in situ hybridization and by hybridization of flanking DNA sequences to a collection of cosmid and bacterial artificial chromosome clones shows that the R domains (euchromatin-like) and V domains (heterochromatin-like) are interspersed. Examination of the effect of genetic modifiers on the variegating transgenes shows some differences among these domains. The results suggest that heterochromatic and euchromatic domains are interspersed and closely associated within this 1.2-megabase region of the genome.
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