ArticleProceedings of the National Academy of Sciences of the United States of America2000
Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 88 citations in OpenAlex.
- Former smoking associated with epigenetic modifications in human granulosa cells among women undergoing assisted reproduction.Scientific reports · 2024Article
- Exploring non-coding RNA mechanisms in hepatocellular carcinoma: implications for therapy and prognosis.Frontiers in immunology · 2024Review
- The Roles of ImprintedCancers · 2020Article
- DAMEfinder: a method to detect differential allele-specific methylation.Epigenetics & chromatin · 2020Article
- Modeling allele-specific expression at the gene and SNP levels simultaneously by a Bayesian logistic mixed regression model.BMC bioinformatics · 2019Article
- Knockdown of Orphan Transporter SLC22A18 Impairs Lipid Metabolism and Increases Invasiveness of HepG2 Cells.Pharmaceutical research · 2019Article
- Cend1, a Story with Many Tales: From Regulation of Cell Cycle Progression/Exit of Neural Stem Cells to Brain Structure and Function.Stem cells international · 2019Review
- The Role of Long Non-Coding RNAs in Hepatocarcinogenesis.International journal of molecular sciences · 2018Review
- Characterization of SLC22A18 as a tumor suppressor and novel biomarker in colorectal cancer.Oncotarget · 2015Article
- An information theoretic method to identify combinations of genomic alterations that promote glioblastoma.Journal of molecular cell biology · 2015Article
- MicroRNAs in liver cancer: a model for investigating pathogenesis and novel therapeutic approaches.Cell death and differentiation · 2015Review
- A mechanistic role for the chromatin modulator, NAP1L1, in pancreatic neuroendocrine neoplasm proliferation and metastases.Epigenetics & chromatin · 2014Article
- DNA methylation as an adjunct to histopathology to detect prevalent, inconspicuous dysplasia and early-stage neoplasia in Barrett's esophagus.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Development of targeted therapy for a broad spectrum of solid tumors mediated by a double promoter plasmid expressing diphtheria toxin under the control of IGF2-P4 and IGF2-P3 regulatory sequences.International journal of clinical and experimental medicine · 2013Article
- Specific changes in the expression of imprinted genes in prostate cancer--implications for cancer progression and epigenetic regulation.Asian journal of andrology · 2012Review
- Loss of imprinting and allelic switching at the DLK1-MEG3 locus in human hepatocellular carcinoma.PloS one · 2012Article
- Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch.PloS one · 2012Article
- Estrogen-mediated epigenetic repression of the imprinted gene cyclin-dependent kinase inhibitor 1C in breast cancer cells.Carcinogenesis · 2011Article
- MicroRNA involvement in hepatocellular carcinoma.Journal of cellular and molecular medicine · 2008Review
- MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.Oncogene · 2008Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Genomic imprinting is a reversible condition that causes parental-specific silencing of maternally or paternally inherited genes. Analysis of DNA and RNA from 52 human hepatocarcinoma samples revealed abnormal imprinting of genes located at chromosome 11p15 in 51% of 37 informative samples. The most frequently detected abnormality was gain of imprinting, which led to loss of expression of genes present on the maternal chromosome. As compared with matched normal liver tissue, hepatocellular carcinomas showed extinction or significant reduction of expression of one of the alleles of the CDKN1C, SLC22A1L, and IGF2 genes. Loss of maternal-specific methylation at the KvDMR1 locus in hepatocarcinoma correlated with abnormal expression of CDKN1C and IGF2, suggesting a function for KvDMR1 as a long-range imprinting center active in adult tissues. These results point to the role of epigenetic mechanisms leading to loss of expression of imprinted genes at chromosome region 11p15 in human tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.