ArticleMolecular and cellular biology2000
Overlapping expression of early B-cell factor and basic helix-loop-helix proteins as a mechanism to dictate B-lineage-specific activity of the lambda5 promoter.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 69 citations in OpenAlex.
- Early B-Cell Factor 1: An Archetype for a Lineage-Restricted Transcription Factor Linking Development to Disease.Advances in experimental medicine and biology · 2024Review
- Progression of Notch signaling regulation of B cells under radiation exposure.Frontiers in immunology · 2024Review
- Article
- Review
- Induction of Epstein-Barr Virus Oncoprotein LMP1 by Transcription Factors AP-2 and Early B Cell Factor.Journal of virology · 2016Article
- Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin type.American journal of human genetics · 2014Article
- The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function.Immunological reviews · 2014Review
- Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages.The Journal of experimental medicine · 2013Article
- Early B cell factor: Regulator of B lineage specification and commitment.Seminars in immunology · 2008Review
- Article
- Molecular biology in acute leukemia.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2006Review
- Neuroblastoma and pre-B lymphoma cells share expression of key transcription factors but display tissue restricted target gene expression.BMC cancer · 2004Article
- Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes.The Journal of biological chemistry · 2004Article
- Inhibition of p300/CBP by early B-cell factor.Molecular and cellular biology · 2003Article
- Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter.Molecular and cellular biology · 2002Article
- The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers.Molecular and cellular biology · 2002Review
- Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Early B-cell factor (O/E-1) is a promoter of adipogenesis and involved in control of genes important for terminal adipocyte differentiation.Molecular and cellular biology · 2002Article
- CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements.The Biochemical journal · 2001Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The basic helix-loop-helix (bHLH) transcription factors are a large group of proteins suggested to control key events in the development of B lymphocytes as well as of other cellular lineages. To examine how bHLH proteins activate a B-lineage-specific promoter, I investigated the ability of E47, E12, Heb, E2-2, and MyoD to activate the lambda5 surrogate light chain promoter. Comparison of the functional capacity of the E2A-encoded E47 and E12 proteins indicated that even though both were able to activate the lambda5 promoter and act in synergy with early B-cell factor (EBF), E47 displayed a higher functional activity than E12. An ability to act in synergy with EBF was also observed for Heb, E2-2, and MyoD, suggesting that these factors were functionally redundant in this regard. Mapping of functional domains in EBF and E47 revealed that the dimerization and DNA binding domains mediated the synergistic activity. Electrophoretic mobility shift assay analysis using the 5' part of the lambda5 promoter revealed formation of template-dependent heteromeric complexes between EBF and E47, suggesting that the synergistic mechanism involves cooperative binding to DNA. These findings propose a unique molecular function for E47 and provide overlapping expression with EBF as a molecular mechanism to direct B-cell-specific target gene activation by bHLH proteins.
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