ArticleMolecular and cellular biology2000
Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1p.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Humanization reveals pervasive incompatibility of yeast and human kinetochore components.G3 (Bethesda, Md.) · 2023Article
- Genetics in ophthalmology: molecular blueprints of retinoblastoma.Human genomics · 2023Review
- RB: mitotic implications of a tumour suppressor.Nature reviews. Cancer · 2012Review
- pRB, a tumor suppressor with a stabilizing presence.Trends in cell biology · 2011Review
- Immunodetection of retinoblastoma-related protein and its phosphorylated form in interphase and mitotic alfalfa cells.Journal of experimental botany · 2011Article
- Tumor suppressor function of BCSC-1 in nasopharyngeal carcinoma.Cancer science · 2009Article
- mars and tousled-like kinase act in parallel to ensure chromosome fidelity in Drosophila.Journal of biomedical science · 2009Article
- Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?Cell division · 2007Article
- Induction of tetrasomy by human papillomavirus type 16 E7 protein is independent of pRb binding and disruption of differentiation.British journal of cancer · 2004Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Retinoblastoma protein (Rb) plays important roles in cell cycle progression and cellular differentiation. It may also participate in M phase events, although heretofore only circumstantial evidence has suggested such involvement. Here we show that Rb interacts, through an IxCxE motif and specifically during G(2)/M phase, with hsHec1p, a protein essential for proper chromosome segregation. The interaction between Rb and hsHec1p was reconstituted in a yeast strain in which human hsHEC1 rescues the null mutation of scHEC1. Expression of Rb reduced chromosome segregation errors fivefold in yeast cells sustained by a temperature-sensitive (ts) hshec1-113 allele and enhanced the ability of wild-type hsHec1p to suppress lethality caused by a ts smc1 mutation. The interaction between Hec1p and Smc1p was important for the specific DNA-binding activity of Smc1p. Expression of Rb restored part of the inactivated function of hshec1-113p and thereby increased the DNA-binding activity of Smc1p. Rb thus increased the fidelity of chromosome segregation mediated by hsHec1p in a heterologous yeast system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.