ArticleMolecular and cellular biology2000
SINE retroposons can be used in vivo as nucleation centers for de novo methylation.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 88 citations in OpenAlex.
- Genome evolution of Mediterranean olives following DNA repeats diversification.The plant genome · 2026Article
- High-resolution methylome analysis uncovers stress-responsive genomic hotspots and drought-sensitive transposable element superfamilies in the clonal Lombardy poplar.Journal of experimental botany · 2024Article
- Repetitive Sequence Stability in Embryonic Stem Cells.International journal of molecular sciences · 2024Review
- Locus-level L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites.Cell genomics · 2024Article
- Characterisation of LTR-Retrotransposons ofInternational journal of molecular sciences · 2022Article
- LTR-retrotransposon dynamics in common fig (Ficus carica L.) genome.BMC plant biology · 2021Article
- DNA Modification Patterns within the Transposable Elements of the Fig (Plants (Basel, Switzerland) · 2021Article
- DNA Methylation Is Correlated with Gene Expression during Diapause Termination of Early Embryonic Development in the Silkworm (International journal of molecular sciences · 2020Article
- DNA Methylation Silences Exogenous Gene Expression in Transgenic Birch Progeny.Frontiers in plant science · 2020Article
- Transposon-associated epigenetic silencing during Pleurotus ostreatus life cycle.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Review
- Putative regulation mechanism for the MSTN gene by a CpG island generated by the SINE marker Ins227bp.BMC veterinary research · 2015Article
- Evolution of DNA methylation patterns in the Brassicaceae is driven by differences in genome organization.PLoS genetics · 2014Article
- Dual function of MIPS1 as a metabolic enzyme and transcriptional regulator.Nucleic acids research · 2013Article
- Mono-allelic retrotransposon insertion addresses epigenetic transcriptional repression in human genome.Journal of biomedical science · 2012Article
- Temporal stability of epigenetic markers: sequence characteristics and predictors of short-term DNA methylation variations.PloS one · 2012Article
- Genomic relationship between SINE retrotransposons, Pol III-Pol II transcription, and chromatin organization: the journey from junk to jewel.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2011Review
- Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms.PLoS genetics · 2011Article
- Aberrant methylation and associated transcriptional mobilization of Alu elements contributes to genomic instability in hypoxia.Journal of cellular and molecular medicine · 2010Article
- Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer.Genome research · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SINEs (short interspersed elements) are an abundant class of transposable elements found in a wide variety of eukaryotes. Using the genomic sequencing technique, we observed that plant S1 SINE retroposons mainly integrate in hypomethylated DNA regions and are targeted by methylases. Methylation can then spread from the SINE into flanking genomic sequences, creating distal epigenetic modifications. This methylation spreading is vectorially directed upstream or downstream of the S1 element, suggesting that it could be facilitated when a potentially good methylatable sequence is single stranded during DNA replication, particularly when located on the lagging strand. Replication of a short methylated DNA region could thus lead to the de novo methylation of upstream or downstream adjacent sequences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.