ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Coregulation of voltage-dependent kinetics of Na(+) and K(+) currents in electric organ.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 65 citations in OpenAlex.
- Resurgent NaNature communications · 2021Article
- Neuronal population models reveal specific linear conductance controllers sufficient to rescue preclinical disease phenotypes.iScience · 2021Article
- Convergent patterns of evolution of mitochondrial oxidative phosphorylation (OXPHOS) genes in electric fishes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Dimensions of control for subthreshold oscillations and spontaneous firing in dopamine neurons.PLoS computational biology · 2019Article
- Ionic current correlations are ubiquitous across phyla.Scientific reports · 2019Article
- Article
- Electric organ discharge diversification in mormyrid weakly electric fish is associated with differential expression of voltage-gated ion channel genes.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Dynamic compensation mechanism gives rise to period and duty-cycle level sets in oscillatory neuronal models.Journal of neurophysiology · 2016Article
- Comparative histology of the adult electric organ among four species of the genus Campylomormyrus (Teleostei: Mormyridae).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Article
- Article
- Spike-threshold adaptation predicted by membrane potential dynamics in vivo.PLoS computational biology · 2014Article
- A sodium-activated potassium channel supports high-frequency firing and reduces energetic costs during rapid modulations of action potential amplitude.Journal of neurophysiology · 2013Article
- The Hodgkin-Huxley heritage: from channels to circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Review
- Neuromodulation independently determines correlated channel expression and conductance levels in motor neurons of the stomatogastric ganglion.Journal of neurophysiology · 2012Article
- A central pacemaker that underlies the production of seasonal and sexually dimorphic social signals: functional aspects revealed by glutamate stimulation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2011Article
- Mechanisms of sustained high firing rates in two classes of vestibular nucleus neurons: differential contributions of resurgent Na, Kv3, and BK currents.Journal of neurophysiology · 2010Article
- Metabolic cost as a unifying principle governing neuronal biophysics.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Conductance ratios and cellular identity.PLoS computational biology · 2010Article
- Geometry and dynamics of activity-dependent homeostatic regulation in neurons.Journal of computational neuroscience · 2010Article
- Circadian and social cues regulate ion channel trafficking.PLoS biology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The electric organ cells of Sternopygus generate action potentials whose durations vary over a fourfold range. This variation in action potential duration is the basis for individual variation in a communication signal. Thus, action potential duration must be precisely regulated in these cells. We had observed previously that the inactivation kinetics of the electrocyte Na(+) current show systematic individual variation. In this study, using a two-electrode voltage clamp, we found that the voltage-dependent activation and deactivation kinetics of the delayed rectifying K(+) current in these cells covary in a graded and predictable manner across fish. Furthermore, when Na(+) and K(+) currents were recorded in the same cell, their voltage-dependent kinetics were highly correlated. This finding illustrates an unprecedented degree of coregulation of voltage-dependent properties in two molecularly distinct ionic channels. Such a coregulation of ionic channels is uniquely observable in a cell specialized to generate individual differences in electrical activity and in which the results of biophysical control mechanisms are evident in behaving animals. We propose that the precise coregulation of the voltage-dependent kinetics of multiple ionic currents may be a general mechanism for regulation of membrane excitability.
Indexed as
Identifiers
10777803PMC6773100W2115002538What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.