ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
c-Raf regulates cell survival and retinal ganglion cell morphogenesis during neurogenesis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Association of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and neurogenesis: a systematic review.Acta neuropsychiatrica · 2025Pooled it
- Age Related Response of Neonatal Rat Retinal Ganglion Cells to Reduced TrkB SignalingFrontiers in cell and developmental biology · 2021Article
- Identification of Retinal Ganglion Cells from β-III Stained Fluorescent Microscopic Images.Journal of digital imaging · 2020Article
- KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Restoration of Opa1-long isoform inhibits retinal injury-induced neurodegeneration.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Neuroprotective Effect of Compound Anisodine in a Mouse Model with Chronic Ocular Hypertension.Chinese medical journal · 2015Article
- Early neural cell death is an extensive, dynamic process in the embryonic chick and mouse retina.TheScientificWorldJournal · 2013Article
- Ras-associating domain proteins: a new class of cyclic nucleotide-gated channel modulators.Advances in experimental medicine and biology · 2012Article
- Localization of cerebellin-2 in late embryonic chicken brain: implications for a role in synapse formation and for brain evolution.The Journal of comparative neurology · 2011Article
- Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration.Molecular and cellular biology · 2011Article
- Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse.Investigative ophthalmology & visual science · 2011Article
- Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reperfusion injury.PloS one · 2011Article
- Article
- Transgenic activation of Ras in neurons promotes hypertrophy and protects from lesion-induced degeneration.The Journal of cell biology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The signaling cascade Ras/Raf/mitogen-activated protein kinases modulates cell proliferation, differentiation, and survival, all key cellular processes during neural development. To better define the in vivo role of Raf during chick retinal neurogenesis, we interfered with Raf-dependent signaling during days 4.5 to 7.5 of embryonic development by expressing a dominant negative mutant of c-Raf (DeltaRaf), which blocks Ras-dependent Raf activation, and by overexpressing wild-type c-Raf. DeltaRaf expression induced an increase in cell death by apoptosis, whereas it did not affect overall cell proliferation and differentiation. In parallel, the number of Islet-1/2-positive and TUJ1-positive retinal ganglion cells were diminished in their definitive layer, whereas there was an increase in the number of mislocated Islet-1/2-positive cells. This disturbed morphogenesis correlated with a disruption of the optic fiber layer. Conversely, c-Raf overexpression caused moderate opposite effects on apoptosis. These results frame in vivo early neurogenesis processes in which c-Raf is essential.
Indexed as
Identifiers
10777790PMC6773115W2134091000What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.