ArticleBiophysical journal2000
A bimodal pattern of InsP(3)-evoked elementary Ca(2+) signals in pancreatic acinar cells.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Glucose and NAADP trigger elementary intracellular β-cell CaScientific reports · 2021Article
- Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction.American journal of physiology. Cell physiology · 2016Review
- Calcium oscillations in a triplet of pancreatic acinar cells.Biophysical journal · 2005Article
- Using total fluorescence increase (signal mass) to determine the Ca2+ current underlying localized Ca2+ events.The Journal of general physiology · 2004Article
- Functional interactions in Ca(2+) signaling over different time and distance scales.The Journal of general physiology · 2000Article
- Mechanisms underlying InsP3-evoked global Ca2+ signals in mouse pancreatic acinar cells.The Journal of physiology · 2000Article
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Authors and funding
4 authors.
Funding
Abstract
InsP(3)-evoked elementary Ca(2+) release events have been postulated to play a role in providing the building blocks of larger Ca(2+) signals. In pancreatic acinar cells, low concentrations of acetylcholine or the injection of low concentrations of InsP(3) elicit a train of spatially localized Ca(2+) spikes. In this study we have quantified these responses and compared the Ca(2+) signals to the elementary events shown in Xenopus oocytes. The results demonstrate, at the same concentrations of InsP(3), Ca(2+) signals consisting of one population of small transient Ca(2+) release events and a second distinct population of larger Ca(2+) spikes. The signal mass amplitudes of both types of events are within the range of amplitudes for the elementary events in Xenopus oocytes. However, the bimodal Ca(2+) distribution of Ca(2+) responses we observe is not consistent with the continuum of event sizes seen in Xenopus. We conclude that the two types of InsP(3)-dependent events in acinar cells are both elementary Ca(2+) signals, which are independent of one another. Our data indicate a complexity to the organization of the Ca(2+) release apparatus in acinar cells, which might result from the presence of multiple InsP(3) receptor isoforms, and is likely to be important in the physiology of these cells.
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